Pharmacodynamics and pharmacokinetics
Once in the gastrointestinal tract, it is absorbed quickly and well. The maximum possible concentration in blood plasma can be observed after 1 hour, excreted after 3-5 hours unchanged in urine (40%), bile and sweat (60%). metabolized in the body .
Improves blood supply to the brain, activates and normalizes redox reactions occurring in it. In ischemic areas of the brain, it stimulates the normalization of regional blood flow. Blood supply to the lower extremities also improves.
Without affecting the spontaneous bioelectrical activity of the brain and the level of GABA, it increases the level of adrenaline , dopamine , norepinephrine and serotonin . In this regard, mood and overall well-being improves.
Shows anorectic activity with long-term use. The drug is in some way an immunostimulant and improves vision.
It is not a carcinogen or a mutagen , and has no embryostatic effect.
Begins to act after the first use. The critical lethal dose is 800 mg.
Indications for use of Phenotropil
What are Phenotropil tablets for?
- various diseases of the central nervous system, especially those associated with impaired blood supply to the brain or metabolic processes;
- impaired attention, memory impairment;
- some types of schizophrenia ( lethargy and apathy as a side effect of the disease);
- increased psychological and physiological stress;
- The indication for the use of the drug is depression of varying severity;
- alcoholism;
- normalization of biorhythms;
- with obesity of alimentary-constitutional origin.
Why was Phenotropil discontinued?
Discussions continue on forums and medical websites about where Phenotropil disappeared from pharmacies and where to buy a nootropic drug.
The disappearance of the drug is due to disagreements that arose between the developer of the pharmacological product (Valentina Akhapkina) and the company. The essence of the dispute is that the inventor, while working with the drug, did not take any measures to improve the composition or expand the range of other forms of release.
The copyright holders of the trademark and patents decided to independently produce the medicine. At this stage, procedures for registering a new type of activity are carried out, and the organization of the business process is carried out.
In 2020, Valenta Pharm officially announced the cessation of production of Fenotropil, citing the initiative of the trademark copyright holders - Roman and Valentina Akhapkin.
Meanwhile, the drug was on the list of vital drugs until 2012. Its pronounced stimulating effect is capable of maintaining a healthy psyche under heavy emotional stress and a busy work schedule.
The planned launch of drug production in 2020 is expected by both patients and qualified specialists. Will be involved in the release of the product.
Instructions for use of Fenoptropil (Method and dosage)
Before using the drug, consult your doctor, he will advise the required dosage and duration of treatment. There is also a universal instruction for Phenotropil.
How to take the pills? Inside, orally. The medicine is drunk immediately after meals, washed down with plenty of water. Better in the morning. The maximum permissible daily dose is 750 mg. On average, it is permissible to take 100-250 mg, and 200-300 mg per day, once. If a single dose is more than 100 mg, the medicine is divided into 2 doses.
For obesity – take 100-200 mg once in the morning for 1-2 months.
For increased performance – 100-200 mg in the morning, for 15 days.
The average duration of treatment is about a month (up to three). If necessary, the course can be repeated for another 30 days.
Nootropil and phenotropil what is the difference
Nootropic drugs have recently been used more and more often. They help cope with stress, relieve headaches and dizziness, improve overall well-being, and make a person more active and attentive. For what reasons does this happen, how do nootropic drugs work? Let's find out in this article.
Take the capsule or tablet before or during meals. After eating, using the drug is not recommended, as it can cause harm to the body. This drug is prescribed to a person for various diseases; the dosage directly depends on this, because each disease has its own treatment features.
Take the drug in the following dosages:
- To improve memory and get rid of cognitive disorders - 1600 mg 3 times a day. Gradually the dose should be reduced to 800 mg.
- For cortical myoclonus – 7 g per day. Gradually the dose is increased by 4 g; the dosage must be increased every 3 days. The maximum amount of the drug should not exceed 24 g per day.
- Sickle cell anemia – 160 mg per 1 kg of weight. This amount is taken in 4 doses.
- pills;
- capsules coated with a protective shell;
- solutions for oral administration;
- solutions for injections.
- improvement of the metabolic process in nerve cells;
- improvement of microcirculation and blood properties.
Scope of application of this drug
- memory loss in older people;
- Alzheimer's disease;
- dementia;
- alcoholism in chronic form;
- flaccid apathetic defective states (psycho-organic syndrome, schizophrenia);
- asthenodepressive syndrome;
- depressive conditions in which antidepressants do not help for any reason;
- sickle cell anemia;
- cerebral palsy;
- mental retardation;
- cortical myoclonus;
- blurred vision due to stroke;
- coma;
- the presence of dizziness of various etiologies.
Nootropics are often prescribed to children with learning disabilities, poor memory and attention.
Are there any contraindications?
- hemorrhagic stroke;
- the last stage of chronic renal failure;
- hypersensitivity to any components contained in nootropic tablets.
The drug is prescribed with caution for patients with kidney disease.
What are the possible side effects?
Also, do not forget about mental disorders, which can manifest themselves as anxiety states or hallucinations. In rare cases, patients may suffer from drowsiness and depression. In addition, after taking the drug, itching may occur on the skin.
Nootropics are rarely addictive, but withdrawal syndrome from drugs in this group is possible. How does it manifest itself? Of course, physical discomfort is unlikely to manifest itself, but an exacerbation of feelings of anxiety, nervousness, and depression is possible. Sometimes insomnia appears.
When driving, you should be extremely careful, since nootropics can cause drowsiness.
If long-term therapy with nootropic drugs is necessary, then doctors should regularly monitor the condition of the renal and hepatic systems and blood. Abrupt withdrawal of the drug is not recommended.
Simultaneous use with alcohol is possible, since neither the content of alcohol nor active substances increases in the blood when taken together. But still, you shouldn’t take the pills with alcohol.
What are the most popular analogies of nootropic drugs?
Probably the most popular analogues of a nootropic drug are:
Price is not the most important factor determining the choice, since the drugs cost about the same. Let's consider other analogues of Nootropil.
Cavinton drugs differ from nootropics in that they have different effects on the human body. since Cavinton preparations are intended to stabilize blood circulation in the brain and are necessary to raise the tone of the veins and arteries. They have a very gentle effect on the body; in most cases they are prescribed to older people.
The big and probably the only drawback of this drug is considered to be its high cost, but it pays for itself quite quickly, thanks to the high quality and speed of action of the active substances.
If a patient has been prescribed nootropic drugs, the attending physicians are obliged to fully advise the person regarding the dosage and regimen.
Indeed, if the drug is abused or used incorrectly, you can encounter an overdose of this drug.
As a result, serious health problems may occur, such as severe dizziness, severe impairment of consciousness, and even coma.
Conclusion
Nootropic drugs are drugs that activate metabolic processes in nerve cells and help improve mental activity. This group includes pyrabene, lucetam, nootropil and phenotropil: we will try to find out which of the last two representatives of this class is better.
Such medications are being developed for patients with neurological problems, if necessary, to protect the brain from destruction by activating nerve cells. This is necessary so that patients can live and feel like healthy people.
Nootropil and phenotropil, what is the difference
The instructions for nootropic drugs indicate that when a person uses these medications, he thinks better, learns, remembers the necessary information, and tolerates physical and mental stress more easily.
For this reason, these medications are of interest not only to people with similar disorders, but also to completely healthy individuals - students, pupils, ordinary people who experience constant nervousness during sessions, classes, who want to accelerate their brain and working ability in turbo mode.
Source: https://golovnoj-mozg.ru/preparaty/nootropil-i-fenotropil-v-chem-raznitsa
Analogues and substitutes
Level 4 ATX code matches:
The drug has no structural analogues containing the same active ingredient. However, there is a class of nootropics that have similar medicinal properties. The most common analogues of Phenotropil are glycine and piracetam ( nootropil ).
What is better Phenotropil or Nootropil?
Nootropil contains another active ingredient - piracetam. The drug must be taken in courses and improvements usually occur after two weeks, unlike Phenotropil, which acts immediately.
However, when taking nootropil, hyperstimulation of the central nervous system , due to the dissociation of the manifestation of some psychotropic effects with long-term use. Its use is justified when it is necessary to quickly mobilize the body's strength under special extreme conditions.
The price of the analogue is undoubtedly less, but the course of the drug is longer.
What's better
When using both drugs, you need to consider:
- When treatment with a nootropic drug is required during pregnancy, preference should be given to Nootropil in the form of a solution for intravenous administration. Other forms of release of Nootropil, like Phenotropil in tablets, are contraindicated for pregnant women.
- Phenotropil and Nootropil in injections and tablets are prohibited for the treatment of persons under 18 years of age. In pediatrics, Nootropil is used in oral solution (allowed for children over 1 year old) and capsules (available from 3 years of age).
Which drug is better in a particular case must be decided by the doctor, since despite the fact that Phenotropil and Nootropil belong to the same pharmacological group, they are not completely interchangeable. Only a specialist can select the correct treatment regimen depending on the diagnosis, concomitant pathologies, the patient’s age, and his body’s response to therapy.
Medicine and healthComment
special instructions
Phenotropil is often used in sports. The drug is included in the list of prohibited doping .
Some compare the effect of Phenotropil with the well-known drug amphetamine , although this is not true. Most likely, the misconception is caused by the prefix “fen” ( phenamine ) in the name. And if the correct dosage is observed, the drug does not cause addiction or withdrawal symptoms .
Use during pregnancy and breastfeeding
Research data does not confirm the negative effect of the active substance of the nootropic drug on the embryo or fetal development.
A negligible amount of derivative components penetrates into breast milk, which does not pose a danger to the baby.
The chemical compounds used in production also do not have a toxic effect on the health of a pregnant woman. However, experts do not recommend using pills during sensitive periods for women.
A drug
used during pregnancy or breastfeeding.
Reviews for Phenotropil
Various forums give a very good assessment of the drug.
Feedback from students : side effects are rare, problems with passing the exam have disappeared, and a thirst for knowledge has appeared. A good way to quickly get back on your feet.
Reviews about losing weight : appetite decreases, mood improves, extra pounds disappear quickly and do not return. The drug is popular among women who are losing weight.
Reviews from doctors about Phenotropil : if the dosage and dosage regimen is followed, the drug helps cope well with fatigue, improves memory and is easily tolerated by patients.
The drug is described on Wikipedia under the name phenylpiracetam .
Side effects
Specific side effects include:
- insomnia when taking medication after 15:00;
- During the first 3 days, skin hyperemia, arterial hypertension and psycho-emotional agitation, a feeling of “hot flashes” may be observed, which completely goes away on its own.
Nonspecific side effects include:
- allergic manifestations: itching, urticaria, redness of the skin, Quincke's edema, anaphylactic shock;
- abdominal syndrome: abdominal pain, heartburn, nausea, vomiting, diarrhea;
- arterial hypertension;
- neurological and mental disorders: headache, dizziness, sleep inversion, irritability, hallucinations.
