Adults can inject Cortexin and Actovegin at the same time

Problems with brain activity can occur not only in older people, but also in the younger generation, and even in children. Modern life with severe stress and a frantic pace sooner or later leads to the development of various pathologies of the nervous system. For this reason, it is necessary to resort to the use of drugs with nootropic effects. Many doctors often prescribe Mexidol or Cortexin, but it is important to figure out which is better. To do this, it is better to consider the important properties of drugs, their composition and application features.

"Cortexin" and "Mexidol" - comparison of which is better to choose

To make the treatment and rehabilitation of a patient with brain damage as effective as possible, neurologists prescribe nootropic drugs. Cortexin and Mexidol are often used in complex therapy. Is it possible to combine them and what effect do they have on the body?

Cortexin: purpose, indications, dosage

The nootropic, neuroprotective drug Cortexin is made on the basis of an animal product - the cerebral cortex of calves . Action of the product:

Improves the metabolism of neurons in the central and peripheral nervous system.
Improves brain function.
Actively used to improve memory.
Positively affects patient learning.
Reduces the toxic effect when using psychotropic drugs (for seriously ill patients).

The drug penetrates the BBB due to its natural origin. Relaxes the vascular system damaged by ischemia, resulting in improved blood flow.

Cortexin is available in ampoules in the form of a white powder. Before use, the powder is diluted in 2 ml of water for injection, and to reduce pain, the drug can be diluted with novocaine or icecaine in the proportion of 1 ml of water to 1 ml of novocaine .

It is administered intramuscularly, slowly. The injection must be given in the first half of the day, since Cortexin stimulates the nervous system.

The medicine is well tolerated and does not cause side effects. An allergic reaction may rarely occur to novocaine, so young children are advised to dissolve Cortexin with water for injection.

Treatment is carried out in a course of 10 injections . Repeat as necessary after 3-6 months .

The drug must be used exclusively as prescribed by the attending physician. Available from pharmacies without a prescription.

Mexidol: action, indications for use

Mexidol also refers to nootropic drugs used in the treatment of patients with impaired cerebral blood supply. It is actively used in the treatment of the consequences of stroke, traumatic brain injury, epilepsy, and cerebral palsy. The effect of the drug is antihypoxic, nootropic, and anticonvulsant.

Mexidol helps:

Establish metabolic processes in the brain.
Relieves him from oxygen starvation.
Prevents the occurrence of seizures.
Improve patient self-control.
Has a beneficial effect on thinking and speech.

Excellently increases the permeability of brain cell membranes and neutralizes the negative effects of cholesterol. Strengthening blood vessels and improving brain nutrition contributes to rapid recovery after ischemia. The state of the nervous system is regulated and actively restored thanks to Mexidol.

The drug is available in ampoules and capsules. It is administered intramuscularly once a day in the morning.

Cortexin and Mexidol - what do they have in common?

The drugs are united by a common group – nootropics. Both medications:

Affects the improvement of brain function.
Activate cell metabolism.
Have a therapeutic effect in the form of increased performance;
Helps improve memory.
Restore blood vessels after injuries and damage.

Since the drugs Mexidol and Cortexin are nootropics, they have a stimulating effect on the nervous system . The action of drugs activates metabolic processes and makes the human brain work actively. Both are used in the morning.

Cortexin and Mexidol complement each other in their action. The compatibility of the drugs is high. Both have a positive effect on various types of ischemia, are well accepted and act quickly.

Difference between drugs

But quite often neurologists prescribe both drugs at the same time, why if the effect is approximately the same?

The fact is that the active ingredients of the drugs Cortexin and Mexidol are different. If Mexidol is a development based on chemical elements, then Cortexin is a natural extract from the brain cells of domestic animals, whose body is as close as possible in structure to humans.

Natural elements are more easily and quickly accepted by the damaged body, the action occurs more efficiently and quickly. Mexidol strengthens this effect. At the molecular level, chemicals are better perceived by the body.

You can compare this process to the construction of a building. If there is a foundation, then brick and concrete together build a strong wall.

This is how Cortexin interacts with Mexidol and restores the damaged nervous system as quickly as possible.

It is important to use drugs in childhood.

Cortexin is well tolerated and accepted by children even in the first year of life, so it is actively used in cases of damage to the nervous system due to birth trauma and hemorrhages.

The drug helps many children with speech and mental development delays. The safety and effective action of Cortexin made it possible to compensate for damage in many children at the stage of active growth and development.

Mexidol is used more in older patients. Then the body is more susceptible to chemical drugs, and the body’s rejection of the drug in the form of side effects is less likely. Often prescribed after injuries or coronary heart disease.

Application Feature

When prescribing Cortexini Mexidol medications at the same time, it is important to understand that one drug is used first - Cortexin, and then Mexidol is administered. Thus, the first prepares the body’s sensitivity to the active substances.

In addition, you can track the occurrence of side effects. Cortexin, as a rule, does not cause discomfort, since it is a more natural and natural substance, while Mexidol can cause a reaction in the body in the form of nausea, increased blood pressure, and dizziness.

For a one-time dose, it is better to choose the following form of administration: Cortexin injections and Mexidol tablets. Although Mexidol is available in the form of a solution for intramuscular administration, in case of joint use it is better to limit oneself to one intramuscular injection - Cortexin.

Source: https://vchemraznica.ru/korteksin-i-meksidol-sravnenie-chto-luchshe-vybrat/

What is the difference and similarity between Actovegin and Cortexin?

Actovegin is made from the blood of a young calf. To produce Cortexin, the cerebral cortex of a calf or pig is used.

Both drugs have similar indications for use.

The use of Cortexin allows one to cope with dyscirculatory encephalopathy, and Actovegin can be used in such a situation as an adjuvant.

Cortexin can be used to treat infants with central nervous system injuries. The use of Cortexin allows you to quickly cope with chronic fatigue. The simultaneous use of drugs in such a situation may cause the development of an allergic reaction.

Actovegin is approved for use during therapy in pregnant and lactating women, and Cortexin is prohibited for use in this category of patients.

Cortexin or Mexidol: which is better? Is it possible to inject together?

These drugs belong to different pharmacological groups, but they have several points of application of therapeutic effects, so some of their effects are essentially similar.

Pharmacological properties

Mexidol is an antioxidant agent, that is, it blocks the formation of free radicals toxic to nervous tissue. These substances are formed when there is a low supply of oxygen to brain cells (neurons) and destroy their membranes, causing rapid death.

The drug also works as an antihypoxant, improving the delivery and use of oxygen by neurons, has nootropic activity - improves thinking, memory, cognitive abilities; reduces seizures, suppresses anxiety, increases the resistance of neurons to adverse factors.

Cortexin is primarily a nootropic. It consists of small protein particles that normalize the production of various chemical compounds in the brain: mediators, growth factors, amino acids.

All of them have multidirectional effects: some stimulate, others inhibit the functioning of neurons. The medicine allows you to achieve their optimal ratio, which is necessary for the full functioning of the brain.

Thanks to this, cortexin protects and promotes the restoration of damaged neurons, regulates metabolic processes, suppresses seizures, and enhances stress resistance.

Indications

To Mexidol:

strokes – death of a part of the brain due to insufficient blood flow;
injuries (bruises of varying severity, concussions) of the brain;
acute and chronic ischemia (lack of blood supply) in the brain and heart muscle;
neuro-circulatory dystonia is a disruption of the autonomic nervous system, affecting internal organs, which is manifested by changes in blood pressure, rapid heartbeat, spasms in the intestines, and attacks of uncontrollable fear;
overdose of drugs for the treatment of mental illness - antipsychotics;
mental and motor agitation against the background of withdrawal syndrome (withdrawal syndrome) in alcoholics;
restlessness and anxiety, stressful conditions;
purulent-inflammatory diseases of the pancreas and peritoneum;
initial mild disorders of thinking and memory.

Reviews from doctors about Cortexin and Actovegin

Igor, 48 years old, neurologist, Vladikavkaz

Both drugs are of animal origin and have an almost identical spectrum of action; they belong to the group of nootropics. But if we rely on clinical studies, each of these medications is good in different clinical cases: Cortexin is preferable in the treatment of central nervous system disorders, Actovegin is excellent for vegetative-vascular dystonia. It is often prescribed to pregnant and lactating women.

Anna, 42 years old, neurologist, St. Petersburg

Despite the fact that the effectiveness of Actovegin has not been clinically proven, I prefer to prescribe it to patients more often than Cortexin. I consider it safer for the body. I select medications depending on the diagnosis and the presence of contraindications. In each individual case, one or another drug turns out to be effective. In some situations, I recommend using these products together. During complex treatment, I sometimes replace Cortexin with Cerebrolysin, which has exactly the same effect and combines well with Actovegin.

To treat circulatory disorders in the brain in adults and children from the day of birth, as well as to support the emotional state of pregnant and breastfeeding mothers, the nootropic drug Cortexin is prescribed.

Cortexin has a complex of low molecular weight polypeptide fractions that penetrate through the BBB to nerve cells. It has nootropic, neuroprotective, antioxidant and tissue-specific effects.

improves brain function, learning and memory processes, concentration, resistance to stress;
protects neurons from damage, reduces the toxicity of psychotropic drugs;
has anticonvulsant and cerebroprotective properties;
Helps quickly restore central nervous system functions after stress.

Compatibility of Cortexin and Mexidol

Cortexin and Mexidol are used to eliminate pathological processes in the central nervous system. This category of drugs is intended to protect the brain from hypoxia and improve blood flow in it.

Cortexin and Mexidol are intended to protect the brain from hypoxia and improve blood flow in it.

How they affect the body

Cortexin contains an active element that consists of a low molecular weight peptide from the brain of pigs and cows. The effectiveness of this medication is based on the stabilization of metabolic processes in nerve cells.

The active substance helps to enhance the protein-synthetic functionality of tissues. Cells are protected from oxidation and hypoxia.

The drug helps restore memory after traumatic brain injury, stroke and the onset of neurodegenerative diseases.

Mexidol is considered an antihypoxic agent. Its effect is aimed at optimizing energy processes in neurons. The drug improves the protection of cell membrane lipids from oxidative processes and reduces the susceptibility of brain tissue structures to a lack of oxygen.

What is the difference

Mexidol is a drug of synthetic origin. Indicated to avoid adverse effects during hypoxia. It is sold not only in injections for internal and intramuscular infusion, but also in tablets.

Cortexin is of animal origin, therefore it is considered natural. Produced only in solution for giving injections. Before use, mix with procaine.

Which is better: Cortexin or Mexidol?

Which drug is best can only be determined by the attending physician based on the indications and condition of the patient. Both medications exhibit nootropic, neuroprotective, antioxidant and tissue-specific effects. The mechanism of action of the drugs is similar, but the difference lies in the price.

Cortexin exhibits nootropic, neuroprotective, antioxidant and tissue-specific effects.

Indications for use

The instructions for use indicate that Mexidol is prescribed for:

acute disturbance of blood flow in the brain;
traumatic brain injury;
neurocirculatory dystonia syndrome;
the occurrence of anxiety;
myocardial infarction;
development of primary open-angle glaucoma;
the appearance of symptoms of intoxication;
Alzheimer's disease;
purulent and inflammatory processes in the abdominal cavity (pancreatitis or peritonitis).

Cortexin is used for:

bacterial and viral damage to the nervous system;
circulatory disorders in the brain;
traumatic brain injury and its consequences;
syndrome of diffuse brain damage;
cerebral autonomic disorders.

In combination with other medications, Cortexin is also used to treat epileptic syndrome, acute or chronic inflammatory processes in brain tissue. In addition, this drug is used to treat children with memory and thinking disorders, developmental delay syndrome, and cerebral palsy.

How to take Cortexin and Mexidol together

Both medications are available in solution form. If they are used simultaneously, their effect is enhanced. However, mixing drugs in one syringe is not recommended. The break between procedures should be 1-2 hours.

Mexidol is prescribed for: acute disruption of blood flow in the brain, traumatic brain injury.

Mexidol can also be taken in tablets. The average dosage is 200-500 mg.

Cortexin is pre-mixed with procaine, saline, sodium chloride or water for injection.

Special instructions for the use of Cortexin and Mexidol

Medicines should be used with caution if there is a history of allergies or bronchial asthma.

Pregnancy and lactation

The drugs cannot be used during pregnancy and breastfeeding, since the active elements pass through the placental barrier and penetrate into breast milk. This can adversely affect the formation of the fetal nervous system.

Childhood

Cortexin is used in pediatric practice for the treatment of neurological diseases in children. The dose and duration of treatment are prescribed by the doctor.

Elderly age

Mexidol is prescribed to older people for Alzheimer's disease, necrotizing pancreatitis, and dementia.

Side effects

When using nootropic drugs, side symptoms may appear. This process is characterized by:

nausea;
dry mouth;
drowsiness;
hives;
itching and redness.

In rare cases, angioedema, low blood pressure, emotional reactivity, and distal hyperhidrosis occur.

Effect on driving

The active substances affect the nervous system, and therefore lead to impaired reaction speed and concentration. You should not drive a car during treatment.

Interaction with other drugs

The interaction of nootropic drugs with other medications is specified in the instructions.

Alcohol compatibility

Not compatible with alcohol.

Overdose

If the dose is not observed, drowsiness occurs.

Conditions for dispensing from pharmacies

Not available without a doctor's prescription.

Storage conditions

Solutions and tablets are stored at room temperature.

Best before date

The drugs are valid for 3 years from the date of manufacture.

What can be replaced

Medicines have analogues:

Cytoflavin.
Piracetam.
Vinpocetine.

Before use, doctors advise studying the annotation.

Drug price

Mexidol is an affordable remedy. The average cost is 290-560 rubles.

Cortexin is considered effective, but expensive. The price for lymphosiate ranges from 1200-1415 rubles.

Reviews

Valentina Ivanovna, therapist, 41 years old, Kaluga I often prescribe Cortexin to children. Although the medicine is expensive, it has a minimum of side effects and contraindications.

Kirill, 36 years old, Lipetsk My father suffered a myocardial infarction. In order for the body to recover faster after surgery, Mexidol and Cortexin were prescribed simultaneously. The treatment was expensive, but gave good results.

Source: https://pankreatit.guru/lechenie/preparaty/prochie/korteksin-i-meksidol

How to take Actovegin and Cortexin?

Cortexin is intended for intramuscular administration. For adult patients, injections of the drug are given once a day for 10 days. In accordance with the instructions for use, a single dose of the drug is 10 mg.

If a massive ischemic stroke is detected in an acute form and at the early recovery stage, it is recommended to administer the pharmacological drug 2 times a day - in the morning and in the evening. The course of treatment lasts 10 days. If necessary, the doctor may prescribe a repeat course after completion of the first course.

In pediatrics, the drug can be used from the first days of a child’s life. For children whose weight does not exceed 20 kg, the instructions for use recommend using a dosage of 0.5 mg per 1 kg of body weight. For children weighing more than 20 kg, the recommended dose of the drug is 10 mg.

Actovegin in the form of an injection solution can be administered intravenously, intraarterially and intramuscularly. The regimen of medication administration and dosage is determined by the doctor depending on the severity of the pathological process. The medication in ampoules, depending on the therapy regimen established by the doctor, can be administered every day or several times a week.

The drug in ampoules is prescribed when metabolic and blood supply disorders in the brain are detected. Initially, in accordance with the instructions for use, the drug is administered intravenously in a dosage of 10 ml for two weeks. At the end of this period, the medicine is administered in a dosage of 5 to 10 ml several times a week for 4 weeks.

Cortexin and Mexidol: which is better, can they be injected together and drug compatibility

Nootropic drugs with a wide spectrum of action against cerebral circulatory disorders are quite common in our country. Two drugs from this group are in great demand among clinicians – Cortexin and Mexidol.

They are successfully used for the purpose of both pharmacotherapy and pharmacoprophylaxis: they have a direct effect on learning processes, memory, mental activity, and increase the brain’s resistance to any adverse effects. But what is better to choose, let’s try to figure it out further.

General information about Cortexin

Cortexin is a modern medicine whose structure is based on polypeptide chains. It is produced on the basis of an extract from the cerebral cortex of cattle and pigs. The composition of this medicinal substance is completely free of prion proteins.

It has been clinically proven that Cortexin has virtually no side effects and has no contraindications for use. Its characteristic properties are the absence of toxicity, allergenicity, immunogenicity, carcinogenicity and teratogenicity. Efficiency is manifested both in monotherapy and in combination with traditional, standardized methods of treatment.

Cortexin is a lyophilized powder for preparing a solution. The active substance is based on complexes of water-soluble polypeptide chains. Dosage – 5 mg and 10 mg. Additionally, the composition contains glycine, which acts as a stabilizer. Thanks to this combination, high nootropic effectiveness is achieved.

General information about Mexidol

Mexidol is a synthetic antihypoxic drug. It contains succinic acid, which provides an amber effect.

This medication has a fairly wide range of pharmacological effects. The mechanism of its action is realized at the level of neurons and blood vessels.

It is widely used in psychoneurological, therapeutic and cardiological practices.

Available in the form of an injection solution of 2 and 5 ml in an ampoule and film-coated tablets of 125 mg. The package contains from 5 to 10 ampoules. The active ingredient is ethylmethylhydroxypyridine succinate. Additional components of the drug are lactose, povidone, magnesium stearate.

The principle of action of the drugs

Both drugs have completely different mechanisms of action:

The mechanism of action of Cortexin is based on its ability to penetrate the BBB. It also directly regulates the content of cyclic nucleotides in the human body. Thus, muscle fibers relax, blood vessels dilate and the volumetric velocity of blood flow in tissues subject to ischemia increases.
Cortexin improves cerebral blood flow and reduces vascular resistance, does not affect the characteristics of general blood circulation (blood pressure, pulse, total peripheral vascular resistance), improves blood circulation in the affected area, and the blood circulation in the healthy area does not change.
It is a vasoactive agent that improves cerebral circulation, enhances the utilization of sugar and oxygen by brain tissue, and increases the brain's resistance to hypoxia.
It also affects the activity of all types of amino acids, the level of neurotransmitters (dopamine and serotonin) in the blood, and has antioxidant properties. While taking Cortexin, neuropsychological indicators improve: concentration and memory increase, anxiety levels decrease, and performance increases.
The second nootropic, Mexidol, has antioxidant and membrane protective effects, which ensure stabilization of the cell biomembrane and affect the synthesis of prostaglandins. The active ingredient of the drug increases the content of polar lipid particles, reduces the viscosity of the lipid layer and increases membrane permeability, reduces the cholesterol/phospholipid ratio.
Clinical effects of Mexidol
The product realizes its properties at three levels - neural, vascular and metabolic. Mexidol reduces pulse blood supply in the vessels of the carotid blood supply and increases it in the vertebrobasilar region due to its ability to penetrate the blood-brain barrier.

Indications and contraindications

The instructions for use for each of the products under consideration clearly state the indications and contraindications. Basically, Cortexin and Mexidol have similar indications for use.

Mexidol is allowed to be used in the following cases:

Acute and chronic cerebrovascular accident, including after a stroke.
Parkinson's disease.
Multiple sclerosis.
Dyscirculatory dystonias, including encephalopathies, the development of which is caused by trauma, decreased blood flow, and inflammation.
Decreased cognitive properties: memory, thinking, attention.
Treatment of vascular pathology in ophthalmological practice.
Cardiac ischemia.

The drug is contraindicated for use during pregnancy, breastfeeding, minors, and with serious kidney or liver pathology.

Cortexin, unlike Mexidol, can be used in all age groups. In childhood, the drug is used from birth for:

Congenital anomalies of brain development.
Delayed speech and psycho-speech development.
Damage to brain structures of various origins in the prenatal period.
Cerebral palsy.
Disorders of attention, memory, learning.

In adults it is prescribed for:

Strokes.
Optic nerve atrophy.
Epilepsy.
Anxious states.
Impaired memory, assimilation of material, thinking.
Alzheimer's diseases.

Cortexin has virtually no serious contraindications for use, except for individual intolerance.

There is no convincing data on the safety of using the drug during pregnancy, so in this case it is better not to use it. Since Cortexin has the ability to penetrate the blood-brain barrier, it is possible that it passes into breast milk. Therefore, it is also recommended to exclude it during lactation.

Drug compatibility

Cortexin and Mexidol can be taken simultaneously. However, do not forget that in this case you definitely need to consult a specialist. In each individual case of the disease, an individual selection of the dose of drugs is necessary.

Large pharmaceutical studies prove that drug-drug interactions are completely harmless.

They complement the mechanism of action and enhance each other's effects. However, it is prohibited to use injectable forms of these drugs, mixing them in one bottle.

This leads to the fact that the active substances begin to interact with each other, changing the structure and effects. It is necessary to administer one drug first, and then the next. Otherwise, various unpredictable treatment results may develop.

Is it possible to inject them at the same time?

Cortexin and Mexidol have different methods of administration, so you can inject them together, adhering to certain rules.

Cortexin is allowed to be administered only intramuscularly. The contents of the bottle are diluted with 1-2 ml of water for injection or saline. The frequency of administration is once a day. For adults, injections of 10 mg of the drug are recommended for 10 days. The choice of dosage for children depends on body weight: with a weight up to 20 kg - 0.5 mg/kg, over 20 kg - 10 mg.

Dosage schedule

Mexidol in tablet form is taken 125-250 mg per day. The maximum permissible number of tablets taken per day should not exceed 6 pieces. Treatment on average should last at least 1.5-2 months. The injection form of the drug is administered intravenously. The ampoule is diluted in 100 ml of saline or 5% glucose and administered very slowly over an hour.

Main differences

Both drugs belong to the same pharmacological group, but have significant differences:

Firstly, these are different active ingredients. There are also differences in the additional components of the drugs. This leads to differences in the mechanism of action, since each individual substance has its own point of application and can influence the same body system in different ways.
Secondly, different routes of administration. Cortexin cannot be administered intravenously, while Mexidol cannot be administered intramuscularly. In patients with thin, poorly defined veins, intravenous administration may be inconvenient.
Thirdly, the drugs have different indications and contraindications. Cortexin is one of the few indicated in childhood, while Mexidol is strictly prohibited.

Which remedy is more effective?

It is not possible to single out the most effective drug among the two presented, since reviews about them are completely ambiguous.

In each individual case of prescription, it is necessary to take into account the individual characteristics of the body, the course of the underlying disease and the presence of concomitant pathology. In one case, the drug may be effective, but in another - not. Therefore, these medications are prescribed in a given situation only by a doctor.

Interaction with other tools

The drugs are compatible with most groups of drugs. But there are still some limitations:

Nootropics should not be taken together with diuretics, as there may be an increase in potassium levels in the blood. This phenomenon is very rare and occurs in isolated cases.
You should also not combine medications with alcoholic beverages (alcohol inhibits the effect of the main substance).
The drugs combine well with other nootropics.

In other cases, no interaction of undesirable effects was observed.

Reviews from doctors and patients

Reviews about the use of these drugs are quite ambiguous; many experts talk about the need to alternate Mexidol and Cortexin. Here are some opinions:

Marina Svintozelskaya, pediatric neurologist: “Most nootropic drugs in our country are intended for adults. Cortexin is the only drug from this group that can be prescribed to children. It gives an excellent effect in children's practice.

Neurological symptoms can disappear with its long-term use.” Victoria Mirina, patient: “I’ve been taking Mexidol for a month now and I’m very pleased with the effect. I suffered an ischemic stroke six months ago. First they injected Cortexin.

While taking the medications, I began to feel very good. Most symptoms have regressed."

So, we can conclude that both drugs are quite effective. Every year, major studies are conducted on their effectiveness in various diseases, and new effects are studied.

The synthesis of these drugs can be considered a “breakthrough” in the treatment of many neurological and therapeutic diseases.

Source: https://Pilyule.com/sravnenie/korteksin-i-meksidol/

Differences between the drugs Actovegin and Cortexin

Cortexin alone is capable of perfectly coping with the pathological condition resulting from discircular encephalopathy. In contrast, Actovegin in such a situation acts as a secondary auxiliary drug.

If this pathology is present, Actovegin can be used simultaneously with Cortexin. In this case, doctors prescribe injecting medications alternating every other day.

Cortexin has been successfully used as the only remedy that helps infants with CNS injury. At the same time, the effectiveness of using the drug has high positive indicators.

When chronic fatigue occurs, Cortexin, unlike Actovegin, has a greater degree of effectiveness. And the combined use of these drugs in such a situation can provoke the appearance of allergic reactions.

Cortexin, unlike Actovegin, is prohibited from injecting women during pregnancy and breastfeeding.

Studies have shown higher effectiveness of Cortexin in the treatment of hypoxic or traumatic damage to brain tissue.

Actovegin showed higher effectiveness in the treatment of vegetative-vascular dystonia, which may be a consequence of disorders of the thyroid gland. The disadvantage of the drug in this case may be nervous-reflex overexcitation provoked by the pharmacological agent.

Cortexin does not have this negative effect, although its effectiveness in treating these disorders is lower.

If the patient has a tendency to develop hysteria and nervous attacks, it is better to use Cortexin for therapeutic measures.

Mexidol or Cortexin, which is better, reviews of joint use

Patient reviews

Actovegin was prescribed in combination with Phlebodia for varicose veins, after the course the skin on the legs acquired a normal color and the pain went away.

Anastasia, 35 years old

Cortexin is a good drug. My daughter was prescribed 5 mg, but she developed an allergy. The doctor divided the dose into 2 doses, the allergic reaction disappeared, and the child’s condition improved.

The average price of Cortexin in Russia is 1100-1200 rubles. per package with a 10-milligram dosage of the drug and 700-850 rubles. per package at a dosage of 5 mg.

Actovegin in ampoules costs 1280 rubles. for 5 pieces, in the form of a solution for infusion - 550 rubles. for 250 ml. The cost of the drug in ampoules for injections is 800 rubles. per pack of 5 ampoules.

As a specialist, I assure you that neither Cortexin nor Actovegin should be taken. And change the specialist who offers them to you for a more adequate one. Both drugs, without scientifically proven effectiveness and safety, are not used in civilized countries. Here is medical information on them:

Here's another source:

If the doctor who suggested these drugs to you does not read modern medical literature, you can print this information out to him.

It depends on why you are prescribed these drugs.

I am familiar with both Cortexin and Actovegen.

We were prescribed it for the development of speech in the child, as there were problems with this.

We took the first course of Cortexin; the injections were quite painful, we didn’t notice much of an effect, but there were no side effects either; by the way, the drug is not the cheapest.

Then there was another course of Actovegen, this drug was cheaper than the first, and the difference was significant, but the result was the same, there were no side effects.

And the third drug, called Cerebrolysin, helped us best - its effect was noticeable.

So it’s hard to say, drugs act differently on all people, everything is selected by trial and error.

Mexidol or Cortexin: which is better?

Problems with brain activity can occur not only in older people, but also in the younger generation, and even in children.
Modern life with severe stress and a frantic pace sooner or later leads to the development of various pathologies of the nervous system. For this reason, it is necessary to resort to the use of drugs with nootropic effects. Many doctors often prescribe Mexidol or Cortexin, but it is important to figure out which is better. To do this, it is better to consider the important properties of drugs, their composition and application features.

Cortexin and Mexidol are nootropic drugs that are widely used in modern neurology. They can have a positive effect on the overall tone of the body and also normalize blood pressure.

They have a beneficial effect on brain activity and promote rejuvenation of the entire body.

It is worth paying attention to some distinctive characteristics of these drugs. They come in different forms, which is why they are often prescribed together. When used together, the effect and effect of medications improves.

Release form and composition

Cortexin is made in the form of a white powder; sometimes there may be a yellowish tint. Before use, this medication is diluted with a special solution and administered by injection.

The composition contains an active element - cortexin, which is a complex of water-soluble polypeptide fractions. It also includes an additional substance - glycine.

Another medicine Mexidol has two forms:

the first form of tablet release. They are placed in blisters of 10 pieces. Can also be sold in jars of 90 pieces
the second form is a solution. It is used for intravenous or intramuscular administration. Available in ampoules. One package usually contains 5 or 10 ampoules.

The two release forms contain the same active element - Ethylmethylhydroxypyridine succinate. In addition to it, there are other additional elements. The tablets contain substances such as sodium carboxymethylcellulose, magnesium stearate, lactose monohydrate, talc, macragol and others.

But the solution contains other elements - injection water and sodium methyl bisulfate.

Positive Action

According to patient reviews, both drugs have good effects. Due to their balanced composition, they are well absorbed in the body. Active elements quickly penetrate the structure of nerve cells through the circulatory and nervous systems. In addition, these drugs have a number of positive features:

they have a positive effect on brain activity
the use of two drugs can improve memory and learning abilities
have a positive effect on concentration
provide protection to neurons from negative influences
reduce the level of harmful effects when taking medications with psychotropic effects
have a positive effect on the state of the nervous and circulatory systems
can be used together, in which case they contribute to the rapid restoration of the functions of the central nervous system after stressful situations.

Treatment of children

Can Mexidol and Cortexin be used for children? Only the appropriate doctor should prescribe the use of two drugs. If the positive effect from their use exceeds the possible health risk, then their use will be permitted. But in any case, you need to consult with specialists.

Application and doses are prescribed only by a doctor. It is worth noting that the medicine Cortexin for children is available in small dosages. But the dose of Mexidol must be prescribed by the doctor. It is important to take the medication only in the prescribed dosage; if it is exceeded, the child may experience unpleasant health problems.

It is imperative to remember that before using any medicine you must carefully study the instructions. Any drug has contraindications under which they should not be taken. Regarding the two medications under consideration, they should not be used during pregnancy and lactation, as well as for problems with the liver and kidneys.

Source: https://lekhar.ru/lekarstva/preparaty-dlja-nervnoj-sistemy/meksidol-i-korteksin-chto-luchshe/

Side effects of the drugs Actovegin and Cortexin

A potential side effect when prescribing Cortexin may be an allergic reaction due to the presence of individual hypersensitivity to the components of the medication.

Unlike Cortexin, Actovegin has a wider range of side effects that can occur when prescribed. The advantage of the drug is the rare occurrence of adverse reactions.

The main side effects when using the drug are:

Allergic reactions, possible appearance of hives and swelling, heavy sweating, increased temperature and hot flashes.
The functioning of the gastrointestinal tract may be disrupted - nausea, vomiting, dyspeptic symptoms, pain in the epigastric area, and diarrhea are observed.
From the cardiovascular system - tachycardia, pain in the heart area, paleness of the skin, shortness of breath, hyper- and hypotension.
From the nervous system, reactions such as weakness, dizziness, overexcitation, loss of consciousness and tremors may be recorded.
You may experience suffocation, a feeling of constriction in the chest area, rapid breathing, difficulty swallowing, and pain in the throat.
From the musculoskeletal system, pain may occur in the lumbar region and in the joints and bones.

If, when using the drug, the first signs of side effects are observed, then it is necessary to immediately stop taking it and carry out symptomatic treatment.

Characteristics of Cortexin

This is a nootropic drug belonging to the group of protein bioregulators. The drug improves metabolic processes in brain structures. In addition, it has antioxidant, anticonvulsant, nootropic and cerebroprotective effects on the central nervous system.

In complex therapy, the drug is used for traumatic brain injuries, vegetative-vascular dystonia, epilepsy, encephalomyelitis, encephalitis, encephalopathies, neuroinfections, cerebrovascular accidents, cerebral palsy, delayed speech and psychomotor development in children, disorders of thinking, memory and learning ability.

The drug is produced in the form of a powder for the preparation of a solution intended for intramuscular injection. Lyophilisate is the active ingredient of the product. The effectiveness of Cortexin is due to the activity of its components, which enter the brain and have the following positive effects:

They slow down the process of lipid oxidation and prevent free radicals from negatively affecting brain cells. Increase cell survival during hypoxia.
They improve the learning process and memory, increase concentration and mental resistance to stressful and psycho-emotional situations.
Reduce the toxic effects of psychotropic substances, protect neurons from neurotoxic effects.
Suppress the activity of pathological foci in the brain.

Mexidol and Cortexin injections at the same time reviews

Cortexin is a multicomponent drug. It contains protein elements, biologically active and vitamin complexes. Cortexin components help restore nerve fibers and normalize central nervous system function.

The pharmacological feature of this drug is the ability to penetrate the blood-brain barrier due to its low molecular weight. This distinguishes Cortexin from other drugs for the treatment of neurological disorders that cause circulatory problems in the brain.

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The mechanism of action of Cortexin is that the amino acid balance is restored. As a result, memory improves, convulsive reactions are suppressed, the aging process of nerve cells is inhibited, and the patient’s mental ability increases. Such pharmacological properties of Cortexin allow it to be used in several areas.

Using Mexidol and Cortexin simultaneously

Cortexin and Mexidol help eliminate various problems that arise from traumatic brain injuries or other brain lesions. But if they are used simultaneously, their effects will only intensify. It is worth noting that the antioxidant agent Mexidol enhances its effect almost after its first dose.

And if you inject two drugs with nootropic and antioxidant effects together, this will quickly get rid of all the unpleasant symptoms that arise from diseases of the brain and nervous system. Mexidol has a beneficial effect during intravenous administration of its analogue.

A course of Cortexin and Mexidol is often prescribed for ischemic brain disease. With simultaneous use, positive dynamics are observed in many patients:

blood circulation in the brain is normalized
intracranial pressure returns to normal
headaches go away
attention is normalized.

Of course, if you take only Mexiol, there will also be a positive effect, but it will come much later.

If the blood circulation in the brain is impaired, along with Mexidol, the doctor prescribes Cortexin injections in parallel. With the combined use of two drugs, patients experience an improvement in their neuropsychological state. Their memory function returns to normal, speech is quickly restored, anxiety disappears, and sleep normalizes.

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There are several main pathologies for which the combined use of Cortexin and Mexidol is allowed:

hemorrhagic stroke;
concussion or bruise of the brain;
epilepsy (complex therapy);
Alzheimer's disease;
senile dementia (vascular type).

The drugs are not used to treat underlying diseases. Their action is aimed at eliminating the consequences of vascular pathologies.

For Mexidol:

severe renal and liver dysfunction;
children under 18 years of age;
individual intolerance to the components of the drug.

For Cortexin: hypersensitivity to the components of the drug.

Treatment of children

Comparative characteristics

We compared Cortexin and its most popular competitor analogues and this is what we got.

In comparison Cerebrolysin

Both drugs are nootropic and have a neuroprotective effect. Cerebrolysin also has neurotrophic activity - this is the ability to replace the functions of dead brain cells.

Both drugs restore cerebral circulatory function and are used after traumatic brain injuries and for mental retardation in children.

Cerebrolysin is used for strokes, spinal cord injuries, for the treatment of endogenous depression, autism, and enuresis.

Cortexin is used for deterioration of memory and thinking, encephalopathy, epilepsy, encephalitis, cerebral palsy in newborns, delayed speech and motor development and poor learning ability of children. Both drugs are used to treat autism spectrum disorders in children from the first year of life.

The simultaneous use of Cortexin and Cerebrolysin in cardiology restores the main indicators of heart function. In ischemic stroke, both drugs act equally, reducing the number of deaths.

In case of delayed speech development, both drugs act equally, but Cortexin has a side effect - agitation of the child. Both drugs cannot be used during pregnancy and lactation, as they can cause allergies. Cerebrolysin, in turn, cannot be used in case of epilepsy and renal failure.

The price of Cortexin is 2 times cheaper than Cerebrolysin, therefore, given their identical properties, preference is given to the former.

Cortexin VS Actovegin

Both drugs belong to nootropics, the active substance of which is of animal origin. They have similar indications for use, but a nootropic drug is also prescribed with Actovegin.

Cortexin treats dyscirculatory encephalopathy well, and Actovegin helps with this pathology only in combination with other medications.

Cortexin remains the only drug in the treatment of newborns with CNS injuries that gives a positive result. Chronic fatigue syndrome is eliminated faster when using Cortexin.

Both drugs cause allergies, but combine well with other medications.

Cortexin is contraindicated during pregnancy and lactation, and Actovegin costs a little less.

Mexidol is popular, but is it good?

Both drugs have similar indications for use:

encephalopathy;
memory and thinking disorders;
decreased learning ability;
absent-mindedness.

Both have powerful neuroprotective effects and regulate dopamine levels in the brain. They are good to use in combination in the treatment of traumatic brain injuries (they give high-quality and quick results), as well as for ischemic brain lesions.

This treatment is prescribed by a doctor and is carried out strictly under his supervision. Mexidol and Cortexin cannot be used during pregnancy, breastfeeding, acute renal failure, and the first drug cannot be used in acute liver failure.

They are approximately the same price.

Tserakson - what's in my name for you?

Both are nootropics, but with different active ingredients. Cerakson is more effective than Cortexin for relieving cerebral edema, therefore, after its use, memory or attention is restored more quickly.

It can be used both in the acute period of the disease and during the rehabilitation period.

Cerakson has more contraindications - they cannot treat children from birth.

And also the short duration of the course of treatment.

The price of Ceraxon is also high compared to Cortexin.

Comparison of ease of use of Cortexin and Cereton

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Cortexin is approximately the same as that of Cereton. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2019-09-19 05:59:38