Tianeptine (stablone, coaxil): instructions for use, reviews, analogues, price

General information about the active substance

Chemical formula of Tianeptine
Tianeptin (Tianeptinum) belongs to the tricyclic antidepressants. They get their name from the triple carbon ring at the base of the element. Tianeptine is used as a sodium salt. It is classified as an atypical representative of tricyclic compounds.

Preparations based on this substance in the retail chain are called Coaxil and Stablon.

Information exchange in brain cells is carried out using a large number of nerve cells-neurons.

Neurotransmitters act as mediators in this process, and representatives of this family such as dopamine, serotonin and norepinephrine are responsible for the development of a depressive state.

Simply put, when the number of these mediators decreases, a pathological condition called depression develops. Antidepressants are designed to normalize the biochemical processes of the brain and increase the number of necessary neurotransmitters.

Tricyclic antidepressants work by increasing the amount of serotonin and norepinephrine by reducing the need for these substances in the metabolic process.

The chemical formula of Tianeptine is as follows: C21H25ClN2O4S.

The drug is in tablet form, based on the active substance Tianeptine and standard auxiliary derivatives. Tablets are available in a dosage of 12.5 mg.

Overdose and its treatment

There are several published articles on cases of coaxial poisoning, as well as deaths. Overdose of Coaxil can produce opioid-like effects and lead to respiratory failure and death due to its direct action on the opioid receptor. Additionally, cardiotoxicity may occur as a result of overdose of this drug.

You should take Coaxil exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may change your dose sometimes. Do not take this medication in larger or smaller amounts or for a longer time than recommended.

Signs of using coaxil

If you are particularly sensitive to the components of the drug, Coaxil causes not only addiction, but also withdrawal symptoms, even if a person uses the drug for therapeutic purposes. Most often, the condition manifests itself in the appearance of insomnia, the development of depression, and a strong desire to take a new dose to alleviate the condition. The following symptoms are also observed, which may indicate a person has taken Coaxil:

1. Severe pain in the body.
2. Nausea and vomiting.
3. Depressed mental state.
4. Insomnia.
5. Psychosis and suicide attempts.

While taking other antidepressants in parallel, the symptoms worsen and the addict, who is unable to withstand the withdrawal syndrome, breaks down, increasing the amount of the drug consumed.

When taking dangerous doses of Coaxil, the following symptoms are observed:

1. Decreased vision and red eyes.
2. Sudden mood swings: from euphoria to psychosis.
3. Anorexia or asthenic syndrome.
4. Crushing teeth, rapid development of caries.
5. When administered by injection, non-healing wounds appear on the extremities.

How to get rid of addiction

One of the main problems of coaxial addiction is that it is very difficult to treat. The craving for the drug persists for years; it is difficult to find tranquilizers compatible with them (for example, it is forbidden to take it with monoamine oxidase inhibitors). Treatment is also complicated by the patient’s physical condition - thorombosis, retinopathy and other concomitant diseases.

The Narconon program consistently addresses the above and other problems. Unlike substitution drug courses, designed for several weeks, it is a procedure consisting of stages with multidirectional effects:

weaning without medication (which is important for psychological dependence) - special assist techniques are used to reduce pain; elimination of toxic consequences according to the “New Life” program, including running, sauna, special diet and taking vitamins, oil mixtures, niacin; restoration of healthy communication skills, assistance in avoiding a return to the previous lifestyle, developing skills for creative problem solving using the methods of “Objective processes”, “Overcoming ups and downs in life”, “Changing conditions in life”; awareness of your obligations, responsibilities and obtaining tools for stopping taking medications in the future - “Personal Values” and “Life Skills”. During the course of the program, all aspects of addiction are eliminated, the patient is prepared for a new page in life without breakdowns and returns to the past

In most cases the process takes up to 10 weeks. The effect lasts for life

During the course of the program, all aspects of addiction are eliminated, the patient is prepared for a new page in life without breakdowns or returns to the past. In most cases the process takes up to 10 weeks. The effect lasts for life.

Adverse reactions

When carrying out therapy with Coaxil and similar drugs, numerous adverse reactions may occur, which, if ignored, can cause serious health consequences:

• from the central nervous system: dizziness, insomnia and nightmares, migraines and decreased concentration;
• from the cardiovascular system, rhythm disturbances and angina pectoris may occur;
• nausea, vomiting, flatulence, dry mouth and refusal to eat are typical for disorders of the gastrointestinal tract;
• breathing apparatus: difficulty breathing, lump in the throat, spasm of the larynx;
• other adverse reactions may include hot flashes, a feeling of heat and lower back pain.

A narcotic effect can occur when the dose of the drug is increased several times. In this case, there is a constriction of the pupil, a slowdown in brain activity, pronounced euphoria, and a state of bliss.

Alcohol intake is not recommended when taking Tianeptine sodium.

Who is Coaxil intended for?

Serotonin plays an important role in the enteric nervous system in the intestinal tract, where it controls intestinal secretions and the movement of digestive material.

Analysis of the results of large-scale epidemiological surveys has shown that anxiety disorders are widely associated with severe depression. This makes an antidepressant with anxiolytic properties particularly unique and attractive.

Coaxil is effective in reducing depressive symptoms of mild depressive disorder and also relieves anxiety symptoms associated with depression.

Doctors usually prescribe Coaxil for depression or anxiety disorder. Some health care providers prescribe Coaxil along with other medications and therapies to treat these conditions. Treatment of severe depression with Coaxil results in greater improvements in neurocognitive function, especially in the areas of error making and verbal immediate memory.

Coaxil has various effects on the body, including increased motivation, suppression of anxiety, cognitive euphoria, increased concentration, rejuvenation and cognitive fatigue.

Instructions for use

Coaxil (Stablon) is available in the form of biconvex coated tablets containing 12.5 mg of the active substance.
Prescribe the medication 3 times a day, 1 tablet (12.5 mg), with plenty of water. For elderly patients or patients with renal impairment, the daily dose is reduced to 2 tablets (25 mg per day). The medicine is intended for oral administration.

As a rule, from the first days of use, the medicine improves mood, normalizes sleep, and reduces anxiety.

It is prohibited to increase the dose for patients with alcoholism; intake in this group of patients should be monitored.

At the end of the course, the dosage should be reduced gradually over 7-14 days.

When treating post-withdrawal states in heroin-dependent patients, the dose is increased to 8 tablets per day and a short-term course of therapy is prescribed for 3-5 days.

Tianeptine and its drugs cannot be used simultaneously with MAO inhibitors. If this rule is ignored, then there is a high risk of developing collapse or hypertensive crisis, fever, convulsions, and even death.

Directions for use and dosage regimen:

Stablon, the price of which is lower than in many pharmacies in your region, is taken orally, by mouth. Every day you need to take 1 tablet three times before meals. Elderly patients are prescribed a lower dose - 2 tablets/day. If necessary, the attending physician may prescribe a dosage greater than that indicated in the instructions. It depends on the severity of the disease and tolerability.

If you are going to buy Stablon on HEP24, please contact our consultants first by telephone or online. This will make it possible to clarify whether the drug is available, what its price is (depending on the manufacturer, dosage, etc.), as well as the cost of delivery.

Consequences of addiction

Dependence on the drug is considered a severe form of drug addiction; in terms of the degree of impact on the body, it can exceed even heroin. It clearly demonstrates how dangerous coaxil is, what it is, a video of the consequences - first of all, purulent and putrefactive processes in tissues and joints, which in some cases lead to amputation of limbs.

Attention! The photos below may shock you! To view, click on “Show”

Also, at the stage of developed drug addiction, very severe withdrawal symptoms are observed. The patient becomes depressed, develops neurasthenia, psychosis, sleep and behavioral disorders, even suicide. Other consequences of addiction include:

• severe pain, especially headaches;
• damage to the walls of blood vessels and thrombus formation, accompanied by rotting of muscle tissue;
• loss of vision;
• nightmares, insomnia;
• severe depression, in which the drug addict cannot control himself and becomes dangerous to himself and others.

pharmachologic effect

Pharmacology:

Pharmacological action: antidepressant. Stimulates the reuptake of serotonin by neurons of the cerebral cortex and hippocampus, with a single administration - by 28%, with chronic administration - by 71%. Increases the spontaneous activity of pyramidal cells of the hippocampus and accelerates the recovery of their potential after functional inhibition. Experimental studies have shown the ability to prevent atrophy of the apical dendrites of pyramidal cells. Improves mood, relieves motor retardation, and increases the overall tone of the body. Promotes the disappearance of somatic complaints (including gastrointestinal ones) caused by anxiety and mood changes. It has a balanced effect and is indicated for both inhibited and anxious depression. Effective in the treatment of major depression and depression in bipolar disorder with or without signs of melancholia, and in depressive disorders of a neurotic and subpsychotic level. Shown to be effective in the treatment of late-life depression, incl. anergic, psychogenic and somatized. Tianeptine is effective in the treatment of depressive disorders during menopause in women. Leads to a reduction in symptoms of anxiety and depression accompanying post-traumatic stress disorder. Analysis of the results of use in patients with a depressive episode in clinical practice (in a psychiatric hospital or on an outpatient basis) showed the compatibility of tianeptine with simultaneously used drugs - phenazepam, diazepam, enalapril, nitroglycerin, etc. It is effective in the treatment of patients with gastric and duodenal ulcers to varying degrees exacerbations with comorbid mental disorders with a predominance of anxiety or depressive symptoms. In patients with chronic alcoholism, it normalizes behavior during the period of abstinence, helps reduce anxiety and depressive symptoms, exhibits vegetative stabilizing activity (by the 4th day of therapy, hyperhidrosis and thirst disappeared in patients, blood pressure normalized, etc.), reduces pathological craving for alcohol. Effective for post-withdrawal disorders (anhedonia syndrome) in heroin addiction. After oral administration, it is quickly and completely absorbed from the gastrointestinal tract. Blood protein binding - 94%. It is evenly distributed in the body and easily passes through histohematic barriers, incl. through the GEB. In the liver it undergoes beta-oxidation and N-demethylation. T_1/2 - 2.5 hours; in patients over 70 years of age, in patients with renal failure T_1/2 increases to 3.5 hours. It is excreted by the kidneys (mainly in the form of metabolites, 8% unchanged). In case of liver failure, incl. with liver cirrhosis in patients with chronic alcoholism, pharmacokinetic parameters do not change significantly. Animal experiments have shown that small amounts pass through the placenta. No effects on reproductive function in animals were detected.

Is Coaxil a drug or not?

Coaxil - what is it, a useful and harmless medicine, or a narcotic? Using the drug strictly as prescribed by a doctor and for a limited period of time has a positive effect. But patients sometimes find it difficult to stop taking it - they are attracted by the “benefits” indicated in the descriptions of the drug and they strive to constantly feel its effect, increasing the dosage and taking the drug for several years in a row. In this case, a severe addiction is formed, with symptoms similar to heroin.

After taking it, the patient feels a surge of strength, euphoria, “loves the whole world” and becomes energetic. But when the drug is discontinued, severe depression develops and sleep disorders begin. Feeling a loss of strength and unpleasant symptoms, the patient takes another pill - this is how drug addiction develops. Sometimes people, especially older people, do not even notice this, believing that they are simply maintaining their strength with medicine.

What is the effect of Coaxil and how quickly will remission occur?

Coaxil is as effective as several classical antidepressants for patients with severe depression, dysthymia, or adjustment disorder. In addition, long-term treatment with Coaxil reduces the incidence of relapse/relapse of depression.

Coaxil has a relatively favorable pharmacokinetic profile. It is not subject to primary hepatic metabolism, has high bioavailability and limited distribution, and is quickly eliminated from the body. Although this provides advantages of Coaxil over tricyclic antidepressants in terms of dose titration, treatment modification, and potential drug interactions, its rapid elimination makes medication and dosage compliance more important.

Tianeptine - description

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Indications for use:

It is used for the treatment of moderate, mild and severe depressive conditions, including in geriatric practice and in patients with somatic complaints, and is used to correct behavior and mood in a state of alcohol and drug withdrawal.

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Directions for use and dosage:

Prescribe 1 tablet 3 times a day (morning, afternoon and evening) before meals. Patients over 70 years of age, as well as patients suffering from PN, should reduce the dose to 2 tablets/day. For patients with chronic alcoholism with or without liver cirrhosis, no change in dosage regimen is required. Since depressive conditions are characterized by a risk of suicide attempts, patients should be under constant monitoring, especially at the beginning of treatment.

If it is necessary to use general anesthesia, it is necessary to warn the anesthesiologist-resuscitator that the patient is taking tianeptine. Treatment with the drug should be discontinued 24 or 48 hours before surgery. In case of emergency surgery, the operation can be performed without first discontinuing the drug, but under strict medical supervision during the operation.

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Contraindications:

Hypersensitivity. Children and adolescents (up to 15 years). Simultaneous use of non-selective MAO inhibitors.

Carefully:

Pregnancy.Breastfeeding.

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Pharmachologic effect:

Antidepressant. Has anxiolytic properties. The mechanism of action of tianeptine is associated with an increase in the reverse neuronal uptake of serotonin by neurons in the cerebral cortex and hippocampus. The drug improves depressed mood. When using tianeptine, there is a decrease in somatic symptoms (in particular, pain in the epigastric region, nausea, dizziness, headache, palpitations, sensations of heat, muscle pain).

Tianeptine normalizes behavior and has a positive effect on character disorders in patients suffering from chronic alcoholism during the abstinence period. The drug helps restore physiological sleep, improves concentration, does not have a negative effect on memory, and does not suppress libido.

There is no increase in body weight when using the drug. Does not have anticholinergic properties and is not addictive.

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Side effects:

Gastralgia, abdominal pain, dry mouth, decreased appetite, nausea, vomiting, constipation, flatulence; insomnia, drowsiness, “nightmare” dreams, asthenia, dizziness, headache, fainting, tremor, fever; tachycardia, extrasystole, cardialgia (including behind the sternum); difficulty breathing, feeling of a “lump” in the throat; myalgia, pain in the lumbosacral spine.

Overdose. Treatment: monitoring vital functions, gastric lavage, symptomatic therapy (ventilation, correction of renal dysfunction and metabolic disorders).

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Release form of the drug:

Tianeptine. Film-coated tablets (12.5 mg).

This page is for informational purposes only! Description of the drug Tianeptine

should not be used by patients to make an independent decision about their use. The decision to prescribe the drug and how to use it is made only by the attending physician as a result of a face-to-face consultation.

Healthy! Useless

Contraindications

Contraindications:

Hypersensitivity, childhood and adolescence (up to 15 years), simultaneous use of non-selective MAO inhibitors. Restrictions for use: Pregnancy, breastfeeding. Use during pregnancy and breastfeeding: Avoid use during pregnancy, as There are no clinical data on the safety of use in pregnant women. Breastfeeding should be stopped during treatment (tricyclic antidepressants pass into breast milk).

Instructions for use

Preparations with this active substance (trade names)

• Coaxil
• Tianeptine sodium

Latin name of the substance

TIANEPTINE

Pharmacology

Antidepressant. The mechanism of antidepressant action is unknown. Unlike other antidepressants, it facilitates the reverse neuronal uptake of serotonin in the cerebral cortex and hippocampus. It has virtually no effect on adrenergic and dopaminergic processes in the central nervous system. It has anxiolytic and moderate sedative effects. In case of moderately severe endogenous, neurotic and reactive depression, anxiety states of various origins, it quickly improves mood, reduces the severity of somato-vegetative disorders, including various pain sensations. Helps restore sleep. Does not increase appetite, does not affect body weight. In chronic alcoholism, it prevents relapses of depression and alcoholic breakdowns.

Tianeptine is quickly and completely absorbed from the gastrointestinal tract. Well distributed in the body. Plasma protein binding is about 94%. Metabolized in the liver by beta-oxidation and N-demethylation.

T1/2 of tianeptine is 2.5 hours, in elderly patients - 3.5 hours.

It is excreted from the body by the kidneys mainly in the form of metabolites, 8% - unchanged.

In case of renal failure, as well as in patients over 70 years of age, T1/2 increases by 1 hour. In case of liver failure, the pharmacokinetic parameters of tianeptine do not change significantly (even in the presence of liver cirrhosis in patients with chronic alcoholism).

Contraindications: TIANEPTINE

Hypersensitivity to tianeptine, simultaneous use of MAO inhibitors, children and adolescents under 15 years of age.

Restrictions on use

It should be used with caution in patients with a history of suicide attempts. When stopping treatment, the dose is reduced gradually over 7-14 days.

When stopping treatment, the dose is reduced gradually over 7-14 days.

The use of tianeptine should be discontinued 24-48 hours before the upcoming surgery under general anesthesia. In case of emergency surgery, the operation is performed without prior discontinuation of therapy under strict medical supervision.

The use of tianeptine is possible no earlier than 2 weeks after discontinuation of MAO inhibitors. However, MAO inhibitors can be used 24 hours after discontinuation of tianeptine.

Impact on the ability to drive vehicles and operate machinery

During treatment with tianeptine, you should refrain from activities that require increased concentration and rapid psychomotor reactions.

Use during pregnancy and lactation

There are no data on the safety of tianeptine during pregnancy, so use is not recommended. If use is necessary during lactation, breastfeeding should be discontinued.

Interaction

When used simultaneously with MAO inhibitors, collapse or sudden arterial hypertension, hyperthermia, and convulsions are possible.

Directions for use and dosage: TIANEPTINE

When taken orally for adults, the average therapeutic dose is 12.5 mg 3 times a day before meals.

Maximum daily dose

when taken orally for elderly patients with renal failure is 25 mg.

Source

Information provided by the Vidal reference book of medicines. Last update of the description 09/28/2011

Features of application:

The medication poses a particular danger at the start of treatment for patients who have previously made suicide attempts. For this reason, they must be closely monitored. It is important for family and friends to inform the attending physician about the slightest changes in the patient’s behavior.

If the patient is awaiting surgery, taking Tianepine should be temporarily suspended 24-48 hours before surgery. In case of emergency surgery, the patient's condition is carefully monitored.

Therapy based on the drug Stablon should be discontinued gradually. Over 1-2 weeks, the working dosage is reduced in several stages. Before you buy Stablon and start treatment, you should stop using MAO inhibitors at least 2 weeks in advance. When crossing back, a 24-hour break is required.

Addiction treatment

Coaxial addiction is quite difficult to treat. The craving for the drug persists for several years. If we take into account the fact that Coaxil cannot be combined with any antidepressants, then the selection of drug therapy becomes difficult. Treatment is selected individually, based on the psychological and physical state of health of the patient. The longer the period of drug use, the longer the rehabilitation will take, since even heroin addiction cannot compare with the severity of the consequences of using Coaxil. However, with timely access to specialists, the chances of recovery increase.

Help a loved one cope with addiction to Coaxil, contact the Zdravnitsa professional treatment and rehabilitation center. Make an appointment with a narcologist by calling the 24-hour hotline.

Side effects

Frequency of side effects:

Education: First Moscow State Medical University named after I.M. Sechenov, specialty “General Medicine”.

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Pharmacological profile

The pharmacological effect of the antidepressant is to stimulate the reuptake of serotonin, increase the activity and restore the functionality of pyramidal cells responsible for the formation of emotions and memory consolidation.

The entire group of medications refers to energizing agents. With the beginning of use, there is an improvement in mood, an increase in tone and motor activity, a decrease in anxiety, normalization of sleep and the absence of somatic pathologies.

Coaxil and Stablon have a pronounced anxiolytic effect, which is aimed at reducing the symptoms of various types of phobias.

The product is quickly absorbed from the gastrointestinal tract in full. It is characterized by stable bioavailability.

The active component is metabolized in the liver and excreted unchanged by the kidneys after 2.5-3.5 hours. In patients over 70 years of age and in patients with impaired renal function, the elimination period is increased by an hour.

Preparations based on the substance Tianeptine have a unique property: unlike known inhibitors, they are a selective serotonin reuptake enhancer (SSRE). In other words, SSRE antidepressants work hard to increase the absorption of serotonin.

The mechanism of their action at the neurotransmitter level is associated with dopaminergic activity. They have a diverse effect on hormonal and enzyme balance.

Can antidepressants cause addiction, and what are the side effects of Coaxil?

The antidepressant Coaxil can be mildly addictive, causing both physiological and psychological dependence.

Coaxil can also cause a euphoric effect similar to that of opioids. This influence, combined with consumer tolerance, may lead consumers to take a larger dose than necessary. That is why it should not be taken in doses greater than 100 mg/day.

Side effects resulting from taking Coaxil are largely similar to those of selective serotonin reuptake inhibitors and are minimal compared to tricyclic antidepressants.

The most common side effects are nausea, constipation, abdominal pain, headache, dizziness, and changes in sleep. Anticholinergic effects occur less frequently with tianeptine than with tricyclics. Hepatoxicity is rare. The dosage should be reduced in elderly patients and those suffering from renal failure.

Where can you buy Coaxil (Tianeptine), the price of which is affordable:

Available medications are presented on the website of our company, which has been the official representative of the international pharmacy chain HEP24 for more than 3 years. We offer profitable purchases of any of the medications, incl. and Coaxil. Our price for it is one of the lowest. You can buy Tianeptine and save a lot. Cooperation with us has some important advantages:

• Access for CIS citizens to high-quality European and Indian medicines from well-known pharmaceutical companies.
• The low price contributes to a more confident fight against the disease. By purchasing medications directly from many manufacturers, we can make the price as affordable as possible for our customers.
• A convenient service helps you buy the necessary drug in a short time.