Pramiracetam is a synthetic derivative of piracetam, the first laboratory-created nootropic, but significantly more powerful.
Discovered and developed by Park-Davis in the 1970s, pramiracetam has been widely studied as a potential treatment for cognitive problems and memory loss associated with Alzheimer's disease and traumatic brain injury, as well as a treatment for various central nervous system disorders.
Pramiracetam has been clinically shown to improve memory in healthy older adults with memory loss and improve overall cognitive function in younger adults with memory problems.
There is evidence that pramiracetam optimizes overall brain function and improves focus and productivity, making it a popular choice among students and others who want to boost their mental abilities.
Pramiracetam has not been approved for any specific use by the USFDA and is not regulated in the United States where it can be legally purchased and used. Pramiracetam cannot be legally sold in Canada, but can be legally imported into Canada for personal use. It is available by prescription in Europe, where it is sold under the brand names Neupramir, Pramistar and Remen for the treatment of dyslexia, ADHD, dementia and memory problems caused by Alzheimer's disease and other neurological diseases.
Pramistar
06.07.2020 19:57
Fig 1. - Pramistar USA from the manufacturer SNS Smart Powders
Improving memory, gaining an additional supply of vigor and vitality during periods of mental stress and shock with the power of thought and a positive attitude is not easy. To do this, it is important to regulate the process at the chemical level of the functioning of the central nervous system. And in this case, a great solution is to try pramistar.
How can I help you
Chicken or quail eggs (minimum 2 chicken eggs per day) will be your best friends throughout the course of treatment. You really need a lot of choline, and pramiracetam works with it. If there is not enough choline in the system, your head will hurt.
A course with piracetam or noopept would be interesting. Don’t overexert your liver/kidneys, eat less fast food, less alcohol, more oatmeal and vegetables.
Operating principle
To understand how effective this drug is, you need to understand the principle of its effect on the body. Here are the main features of this process:
- After entering the body, pramistar is quickly absorbed. After 2 hours, the highest concentration of the active substance in the blood is observed.
- The medicine has a direct effect on the central nervous system. It ensures the capture of choline, a substance necessary for vigor and mental clarity.
- At the same time, the drug has an effect on neurocytes, increasing the viscosity and plasticity of membranes. As a result, cognitive processes in the brain occur actively, which contributes to better assimilation of the information received.
After taking pramistar, it is eliminated from the body within 6 hours. At the same time, it has no effect on the liver and does not bind to blood proteins. The drug leaves the body in urine. Therefore, when using it, it is important to monitor the condition of the kidneys and urinary system.
The best racetam, is there one?
The three most popular racetams are known: aniracetam, oxiracetam and pramiracetam. “Which substance is the best?” is a common question from many people on various forums.
All of these remedies have similarities, but different side effects, which is confusing. Considering that they all have completely unique chemical components, this means that each substance will act on the brain differently.
Each of this chain has excellent nootropic effects. For example, the ability to develop memory and acquire new skills. However, there are also nuances in the difference, as well as in the consequences after use.
Properties
Pramistar is an excellent remedy from the racetam family that can normalize processes occurring in the central nervous system. When using it for treatment, patients and doctors note its following properties:
- Nootropic. The drug stabilizes the amount of choline, trapping it in the brain. At the same time, it facilitates the passage of neural impulses. As a result, microcirculation of brain tissue is activated in a person. Therefore, there is activity in behavior associated with the emergence of interest in ongoing life processes and events. Due to the presence of this property in Pramistar, it is prescribed to patients with depressive mental disorders.
- Mnemotropic. Pramistar actively affects areas of the brain responsible for memory and storage of information. Therefore, while taking the medicine, patients’ ability to assimilate new information and remember it increases.
- Adaptogenic. While taking Pramistar, patients note a surge of strength and vigor. This is due to an increase in the overall tone of the body, which is expressed in the desire to be active in everyday activities.
These are the main aspects of the drug’s effect on the human body. With its help, patients with various ailments manage to stabilize their condition and return to their usual rhythm of life.
Benefits and effects of Pramiracetam
Pramiracetam is a true nootropic drug created specifically to improve cognitive function. Its benefits and effects include the following:
- Improve Memory Pramiracetam is a proven memory enhancer, widely tested for several decades and proven effective in both animal studies and clinical trials of young people with cognitive impairment due to brain injury.
Pramiracetam improves memory by stimulating the hippocampus, the part of the brain primarily responsible for creating new memories, and acting as a powerful anti-amnestic drug that reduces forgetfulness. This dual action makes pramiracetam a very effective memory enhancer, and many users also report significant improvements in memory speed, which have been confirmed in animal studies.
- Enhances Alertness and Enhances Learning Pramiracetam's reputation as a "General Cognitive Enhancer" that increases alertness and enhances learning has made it a popular choice among students looking for a reliable study aid.
Although no human studies on these specific effects have been documented, animal studies suggest that pramiracetam promotes mechanisms underlying learning and memory enhancement by increasing the activity of the neuronal nitric oxide synthase (NOS) type in the hippocampus. NOS activity is associated with neural development and brain plasticity, which are critical for all aspects of cognition.
Pramiracetam is also known to increase the uptake of high-affinity choline in the hippocampus, thereby indirectly fueling the production of acetylcholine, an important neurotransmitter that is closely associated with learning and cognition.
- Treatment of Dementia Open studies in patients with primary degenerative dementia show that Pramiracetam is effective in reversing amnesia, significantly enhancing memory and reducing forgetfulness.
Other studies that measured the effects of pramiracetam and other racetam-class nootropics in patients with mild to moderate dementia observed measurable improvements in cognitive function and memory. These results are likely explained, at least in part, by the nootropic enhancement of existing neurotransmitters.
Although pramiracetam has not been approved as a treatment for Alzheimer's disease in the United States, it is commonly prescribed in Europe to treat dementia and other cognitive problems associated with Alzheimer's disease and other neurological disorders.
- Social Development While there is no documented research into the effects of pramiracetam on social development, many users report that it makes them more conversationally creative and socially fluent. This effect may be explained, at least in part, by the purported emotion-numbing effect of pramiracetam, which is sometimes described as similar to Ritalin. This effect may reduce social anxiety and, in turn, enhance social development.
- Neuroprotective Potential Pramiracetam is known to have significant neuroprotective effects that can improve cognitive performance in people who have suffered traumatic brain injury.
Studies have also shown that it has a pronounced neuroprotective effect when used during coronary artery bypass surgery, as well as in the treatment of cognitive impairment of cerebrovascular origin.
Indications for use
Pramistar is a nootropic drug that improves cognitive abilities and memory. Moreover, the medicine has an antidepressant effect on the body, which makes it possible to use it for various mental disorders. Here are the main conditions for which pramistar is prescribed:
The drug is used:
- After suffering a stroke. Pramistar affects areas of the brain responsible for speech and memory. Therefore, after a long course of treatment, the patient is able to restore the ability to speak and retain information.
- Dementia. Deterioration of cognitive functions leads to dementia. To prevent this from happening, it is necessary to stimulate brain activity.
- Depressive disorders. Lack of interest in life and loss of motivation for various activities often lead to the development of severe forms of depression. To prevent this from happening, doctors prescribe pramistar, which helps stabilize the mental state.
Pramistar is suitable for use during periods of emotional lability, when frequent mood changes occur due to disturbances in the functioning of the central nervous system. The medicine helps stabilize the condition.
Side effects
Pramiracetam is generally well tolerated even at high dosages, and very few side effects have been documented.
There are infrequent reports of minor and transient side effects, including headache, gastrointestinal upset, and feelings of nervousness or agitation.
In many cases, side effects are associated with high dosage and can be prevented by reducing the dosage.
Choline depletion headache is a common side effect of racetam-type nootropics and can possibly be prevented by taking pramiracetam in combination with choline supplementation.
Pramiracetam is not addictive and no significant side effects from long-term use have been reported. There is evidence that pramiracetam may even promote brain health and even restore function in the aging brain.
Instructions for use
Before starting treatment, it is important to pay attention to the nuances of using the drug. Instructions for use of pramistar describe in detail the features of taking the medicine:
- The medicine is prescribed in a dosage of no more than 1200 mg per day.
- For this reason, it is recommended to divide it into 2 doses of 1 tablet.
- It is better to take the next one no later than after 6 hours. This time is equal to the withdrawal period of the drug. To maintain a stable state, it is important not to exceed the time between doses of Pramistar.
- For elderly people, pramistar is prescribed in the same dosage without any adjustment.
For people who have kidney disease, it is important to use pramistar with extreme caution, since due to its elimination by them, the condition may worsen. If you feel the slightest deterioration, you should immediately inform your doctor.
Compatibility with other nootropics
Pramiracetam works well on its own, but can also be a powerful potentiator for other nootropics, increasing their effectiveness.
It is a particularly effective potentiator for other racetams, making it a natural addition to most nootropic stacks.
Adding a choline source supplement to a pramiracetam stack may have several benefits. Not only can it enhance the effects of pramiracetam, but it can also prevent headaches, which is the most common side effect.
Since Pramiracetam has such powerful effects, it is recommended to use it on its own for a trial period before combining it with other nootropics.
Combination of Pramiracetam and Oxiracetam
Combining pramiracetam with an energy enhancer such as adrafinil (banned in the Russian Federation) or oxiracetam can increase mental alertness and prolong it for a longer period.
Approximate dosages per day: pramiracetam 300 mg + oxiracetam 750 mg + Citicoline 300 mg.
Combination of Pramiracetam and Aniracetam
Using pramiracetam with a powerful anti-anxiety agent such as Aniracetam can give users increased focus and alertness, improving mood and reducing feelings of mental stress and anxiety. Some users say that this stack promotes social development and improves public speaking ability.
Approximate dosages per day: pramiracetam 300 mg + aniracetam 750 mg + Citicoline 300 mg.
Reviews
- Anna, 25 years old
After reading reviews about Pramistar, I decided to try this drug during the summer exam. Before this, I used other types of nootropics, but did not get much effect from them. I recently came across this particular option in a medicine catalog. I drank it 2 times a day with plenty of water. As a result, I passed all the exams easily and successfully. After that I took a break until next time.
- Nina Ivanovna, 60 years old
After retirement, I often began to forget everything. Moreover, the matter concerned not only situations when I put the thing down and could not remember, but literally everything. For example, I went to the barn at the dacha and forgot why. At first I just laughed at this - they say, my pension has arrived, it’s time to write notes and put them in my pocket in case I get lost. And then somehow the fun passed, and things like this started to become alarming. I went to a neurologist at the local clinic, and the doctor prescribed me Pramistar. I took the course, and my memory returned to normal. Now I even go to the store without notes.
Analogs
Among the analogues, the following nootropic drugs can be distinguished:
- Piracetam is the leader of all Racetams, improves memory, thinking, learning and memorization. Stimulates both brain centers;
- Pramiracetam is the most powerful drug. Its effect lasts for 8 hours after the first dose;
- Aniracetam - the effect of its action occurs in a short time. Reduces anxiety, stabilizes the emotional background, activates the functions of creativity and eloquence.
Before starting treatment, you should definitely consult your doctor.
