Negrustin is a herbal medicine with antidepressant activity.
The active component of this herbal medicine is the extract of the herb St. John's wort.
The effect of the drug Negrustin is the combined effect of all components in its composition.
Being a herbal preparation with antidepressant activity, Negrustin has a beneficial effect on the functional states of the central as well as the autonomic nervous system.
Hypericin is the main substance contained in St. John's wort extract. This biologically active substance has the ability to suppress (inhibit) the activity of the enzyme monoamine oxidase type A. Also, flavonoids contained in St. John's wort extract are able to bind to benzodiazepine receptors and thus have a pronounced sedative effect.
Reviews of Negrustin indicate that after using this herbal medicine, mood improves, mental and physical performance increases, and the processes of falling asleep and sleep are normalized.
Contraindications for taking Negrustin
The use of Negrustin is contraindicated:
- women during the period of bearing a child (pregnancy);
- women during lactation (breastfeeding);
- with allergic reactions to St. John's wort extract;
- with endogenous depression;
- in case of photosensitivity to the use of St. John's wort preparations;
- when used simultaneously with other drugs that can cause the development of photosensitivity;
- with fructose intolerance;
- with photodermatitis;
- in childhood.
Composition of Negrustina
One capsule of Negrustin contains 0.425 g of dehydrated extract of St. John's wort.
It also contains additional ingredients: MCC, lactose, aerosil, calcium dihydrogen phosphate, talc, gelatin, magnesium stearate, copper chlorophyll complex, sodium lauryl sulfate, iron oxide, titanium dioxide, water.
The Negrustin solution contains St. John's wort extract as an active ingredient.
It also contains additional components: 1,2-propanediol, glycerin, sorbitol, flavoring.
Side effects of Negrustin
The instructions for Negrustin inform that when using this herbal medicine, adverse reactions may occur:
- the appearance of allergic reactions;
- development of skin itching;
- the appearance of skin rash, eczema;
- the appearance of skin pigmentation;
- development of photosensitivity;
- increased sensitization to animal fur;
- the occurrence of anxiety, excessive fatigue, headaches;
- development of nausea, dry mouth, flatulence (accumulation of gases in the intestines), abdominal pain;
- development of anemia.
Release form
The product is available in the form of hard, opaque gelatin capsules, which have a matte red body and a green cap. The capsules contain green-brown or gray-brown granules with a specific odor. The tablets are packaged in blisters of 10 pieces; cardboard packs may contain 3, 4, 6 or 10 blisters.
The solution for internal use has a brown or red-brown color, it is transparent, and has a pleasant aroma. If the solution is stored for a long time, it may become cloudy or precipitated. The solution is packaged in dark glass bottles of 50 ml or 100 ml. The bottle is packaged in a cardboard box, which also contains a measuring cup.
Precautions when taking Negrustin
Before taking the drug Negrustin, it is strongly recommended to consult with your doctor in the relevant specialty.
In order to reduce the likely risk of side effects, the use of the drug Negrustin should be started with the minimum recommended dosages.
During the period of use of the drug Negrustin, it is necessary to avoid prolonged exposure to bright sunlight and visiting a solarium.
With simultaneous use of the drug Negrustin with cyclosporine, as well as protease inhibitors, indinavir, indirect anticoagulants (phenprocoumon, warfarin), amitriptyline, digoxin, nortriptyline, theophylline, the therapeutic effect of Negrustin on the body may be weakened.
Negrustin description and instructions for use of the drug.
Drug name:
Negrustin
Release form, composition and pack
Hard gelatin capsules, with a red matte body and a green matte cap; the contents of the capsules are grayish-brown granules with a characteristic aromatic odor.
1 caps. dry extract of St. John's wort herb (3.5-6.0: 1) 425 mg.
The solution for oral administration is clear, brown to red-brown in color with an aromatic odor; During storage, a slight sediment or cloudiness may form.
1 ml liquid extract of St. John's wort herb (0.7-1.3:1) 791 mg.
Excipients: glycerol, propylene glycol, sorbitol 70%, flavorings.
Clinical and pharmacological group: Herbal product with antidepressant activity.
pharmachologic effect
Herbal product with antidepressant activity. It has a beneficial effect on the functional state of the central and autonomic nervous system.
The main component of St. John's wort extract is hypericin. It is assumed that hypericin is capable of inhibiting the activity of MAO type A. Flavonoids included in the St. John's wort extract bind to benzodiazepine receptors and have a sedative effect.
When using the product, your mood improves, mental and physical performance increases, and sleep normalizes.
Pharmacokinetics
The effect of the Negrustin product is the combined effect of its components, so kinetic observations are not possible; All together the components cannot be traced using markers and biostudies.
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Indications
- mild to moderate depression;
- states of anxiety and restlessness;
- psychovegetative disorders.
Dosage regimen
For adults and children over 12 years of age, the product is prescribed 1 capsule. 1-2 times/day or 1 ml of solution 3 times/day.
The course of treatment is 6-8 weeks. If necessary, repeated courses of treatment are possible.
Capsules should be taken at the meal stage, without chewing and with sufficient liquid.
The solution can be taken undiluted or with a small amount of liquid at mealtime.
Side effect
Regarding the digestive system: symptoms of dyspepsia.
Dermatological reactions: photosensitivity.
Others: allergic reactions.
Contraindications
- endogenous depression;
- history of photosensitivity to taking St. John's wort products;
- high sensitivity to the product.
Pregnancy and lactation
Despite the lack of data on the harmful effects of the product, taking Negrustin during pregnancy and lactation is possible only if the potential benefit to the mother outweighs the possible risk to the fetus or newborn.
special instructions
At the stage of taking the product, especially fair-skinned patients should avoid prolonged exposure to sunlight and visiting solariums.
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The simultaneous use of other drugs that cause photosensitivity should be avoided.
Due to the presence of sorbitol in the oral solution, it should be taken into account that with each intake of the product, the body enters within 121 mg of sorbitol.
When prescribing an oral solution to patients with diabetes mellitus, it should be taken into account that 1 ml corresponds to 0.01 XE.
Caution should be exercised when prescribing the oral solution to patients with fructose intolerance.
It is not recommended to use Negrustin simultaneously with MAO inhibitors.
Use in pediatrics
The product should not be prescribed to children under 12 years of age due to insufficient data.
Impact on the ability to drive vehicles and operate machinery
The drug may have an effect on the patient’s psychophysical abilities, especially when taken simultaneously with tranquilizers or alcohol.
Overdose
To date, there is no data on cases of overdose of the Negrustin product.
Symptoms: the described side effects may increase.
Treatment: if taking the product in large doses, avoid exposure to the sun for 1-2 weeks.
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Drug interactions
When Negrustin is used simultaneously with cyclosporine, indinavir, protease inhibitors, indirect anticoagulants (phenprocoumon, warfarin), digoxin, theophylline, amitriptyline, nortriptyline, the effect of Negrustin may be weakened.
When Negrustin is used simultaneously with other antidepressants (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram), side effects may increase (nausea, vomiting, fear, psychomotor agitation).
Concomitant use of photosensitizing drugs may lead to increased photosensitivity.
Concomitant use of oral contraceptives may lead to bleeding.
Storage conditions and periods
The drug should be stored at a temperature not exceeding 25°C. The shelf life of capsules is 3 years. The shelf life of the solution is 4 years.
Attention! To use the drug "Negrustin" you should obtain a detailed and complete consultation with your doctor. The instructions are provided solely for familiarization with “ Negrustin ”.
Sources of information: rsml.med.by, mednet.by, drugs.com, webmd.com.
Effect of the drug
The active substance of the medicine is St. John's wort herb extract. Negrustin has an antidepressant and sedative effect and affects the central nervous system. While taking the drug, the level of hormones responsible for mental balance and calm increases. Prescribed for the following conditions:
- increased anxiety;
- manic state;
- phobias;
- asthenia;
- depression;
- agitation caused by pain or itching.
The drug is not used in a state of severe depression; Negrustin is also contraindicated for children and pregnant women. An analogue of the product that contains St. John's wort can harm this most vulnerable category of people. According to studies, such drugs either did not have the expected effect or provoked side effects. Therefore, the issue of treatment of psychological and neurological diseases should be resolved individually with a specialist.
special instructions
During treatment with the drug, you should not stay in sunlight for a long time. This warning primarily applies to people with fair skin.
There is no need to allow simultaneous use of other drugs that cause photosensitivity.
Due to the presence of sorbitol in Negrustin, it is necessary to take into account that each time the drug is taken, approximately 121 mg of sorbitol enters the body.
If the solution is prescribed to people with diabetes, it should be taken into account that 1 ml of solution corresponds to 0.01 XE.
Prescribed with caution to those diagnosed with fructose intolerance.
There may be an effect of the drug on the ability to drive vehicles and operate precision machinery, especially if Negrustin was taken simultaneously with alcohol.
DEPRIM reviews from those who took it
Prices for the drug DEPRIM
Name:
Agent Provocateur I always considered the drugs “Deprim” and “Persen” to be herbal dummies, so I never bought them.
She preferred other sedatives. But one specialist told me that Deprim is a really effective drug. Of course, it will not remove advanced depression, but it will cope with incipient depression. And so, when it started to “cover” me, I remembered about Deprim. Description Herbal product. Contains anthracene derivatives - mainly hypericin, pseudohypericin; flavonoids - hyperoside, quercetin, rutin, isoquercetin, amentoflavone; xanthones - 1,3,6,7-tetrahydroxy-xanthone; acylchloroglucinols: hyperforin with small amounts of adhyperforin; essential oils; oligomers; procyanidins and other catechin tannins; caffeic acid derivatives, including chlorogenic acid. It has a mild antidepressant, sedative and anxiolytic effect, as well as a stimulating effect on the gastrointestinal tract, blood circulation, and a general tonic effect. It is believed that the antidepressant effect of the plant is due to the ability of its active substances to inhibit the reuptake of serotonin and other neurotransmitters, as well as the effect on melatonin metabolism. Due to the high content of flavonoids, the plant has an anti-inflammatory effect. It has been established that hyperforin inhibits the growth of gram-positive bacteria Streptococcus pyogenes and Streptococcus agalactiae. The effectiveness of hyperforin against penicillin-resistant strains and methicillin-resistant strains of Staphylococcus aureus has been shown. At one time I tried drinking St. John's wort as an antidepressant. But I didn’t get the desired result. Deprim, on the other hand, is a drug based on St. John's wort, so I had no faith in it. But as a specialist explained to me, herbal tea from St. John’s wort contains a very low concentration of the necessary substances to provide an antidepressant effect. Pills are another matter. A package of 30 tablets costs 250 rubles.deprim Instructions for usedeprim Tablets are green in color and taste quite pleasant - herbal.deprim Method of usedeprim Composition Indications for use and contraindicationsdeprim Experience of use The drug is ambiguous for me. At first it seemed to me that it was working, and wow. I felt cheerful, my mood began to level out in a positive direction. And then, suddenly everything was cut off. And my mild depression turned into a long one. I took pills, but every day my condition worsened. In general, Deprim was discontinued for me, they prescribed another treatment regimen with more serious drugs, and only after about a month did I feel an improvement. Score two. | irecommend.ru Name:
GrainOl
Review:
Hello.
I confess, lately I have often been nervous, angry, and, of course, crying at the slightest trifle, and sometimes even without it. There were reasons, of course. But they were there at the beginning, and then, like a snowball, they began to accumulate small troubles. insults, failures. Well, I got to the point where I was shedding tears like a professional fountain))). At some point I decided that I was already getting scared because of my condition and went to the doctor. The doctor advised me to take one drug, about which I can only say that it is addictive... that’s enough for me, I don’t want to go on pills! I went to the pharmacy and just consulted the pharmacist. She asked me to give me a medicine that does not cause a hypnotic effect, but at the same time calms me down. The pharmacist gave me DEPRIM, for which I am very grateful. In fact, the medicine helped me a lot. My mood improved and stabilized. I started smiling more often than crying. I began to accept the pokes of fate more easily. There was no drowsiness; on the contrary, I became more energetic and cheerful. The apathy went away. I began to feel the effect of the drug on about the third or fourth day. Read the instructions for Deprim carefully. There are some important things you should know. For example, who should not take this drug. One package contains 30 tablets, subject to the rules of administration (3 tablets per day), the package is enough for 10 days. But I drank 2 a day, which was enough for me. The tablets are easy to swallow; their surface has no taste. No allergies were caused. And they really helped me calm down and become stronger. The cost of the drug in different pharmacies varies greatly. I bought the first package for 160 rubles, but for some reason the second one for 280. I saw it for 300-something. | otzovik.com Name:
MMro
Review:
I already feel somehow different! More and more often I write about means that reduce moral excitability (maybe it’s time to see a doctor?). Before that, I talked about Vitamins of group B and Magnesium + Vitamins of group B. All these drugs are aimed at maintaining the nervous system in a calm state. How did I live to see Deprim? Problems began at work, maybe not the most serious in life, but for some reason I lost it. I cried all day with or without reason. I could cry because I didn’t buy something for the house when I was leaving work (I’m so stupid that I forgot to buy bread). I don't know what it was and where it came from... My mother recommended Deprim to me, since it is herbal and does not inhibit the reaction and does not cause drowsiness (and stupidity). Immediately after taking the first tablet (you need to take 3 tablets a day, but believe me, when you are stressed, you will not miss a single dose) I felt a little more cheerful, lighter and my eye stopped twitching, although before that it had been twitching for three days in a row. The tablets work immediately. On the first day by the third pill I was 80 percent calm, and the next day I was 99 percent calm! In a conflict situation at work, I behaved unexpectedly calmly. And after that I didn’t feel excruciatingly painful in my soul and the questions from the series disappeared from my head: what is the meaning of life and what is my purpose in life (it’s funny now). At the moment I have been taking Deprim for 5 days. Condition is good, calm, balanced. It doesn’t lift your mood (I can’t even imagine how that’s possible...), but it definitely calms you down. IMPORTANT: I am not sleepy, I am not lethargic, my activity is not reduced. | irecommend.ru
