Valdoxan is a tablet drug used in psychiatry, less often in neurology. The medicine is produced in France and is used in many European countries and beyond. According to the instructions for use, the drug is effective for depressive disorders of any etiology. It is available only with a doctor's prescription and can be used exclusively for its intended purpose. And although the drug does not cause addiction, self-medication with this drug can lead to serious disruptions in the functioning of the entire body.
Radar
Valdoxan was included in the system of medicines registered in Russia on September 16, 2015.
Basic information about the drug:
- name – Valdoxan;
- pharmacotherapeutic group – antidepressants;
- ATX code - N06AX22;
- active ingredient – agomelatine;
- release form - tablets (oblong, covered with an orange-yellow coating);
- terms of sale - according to prescription.
"Neuroplant"
The analogues and generics available for the German drug Valdoxan must be supplemented with Neuroplant. It has a herbal composition, that is, it is completely natural. The main active ingredient is St. John's wort extract, which gently relieves depression. Unlike St. John's wort in its natural form, the extract has a more concentrated composition, and one tablet contains a dosage that cannot be obtained by taking a herbal drink from the plant or tincture.
If we consider the analogs available for the drug Valdoxan, reviews of Neuroplant will be predominantly positive. This is due to the fact that the medicine has no side effects. A contraindication to taking the drug is hypersensitivity to St. John's wort or a previously noted allergy to herbal remedies.
Compound
The antidepressant was developed on the basis of agomelanin and is widely used in neurological and psychiatric practice.
The active component is an antagonist of serotonin receptors and a stimulator of the response of melatonin receptors (MT1, MT2).
One tablet contains 25 mg of active ingredient.
The production also uses compounds that improve the absorption of the composition base:
- magnesium stearate;
- corn starch;
- lactose monohydrate;
- Povidone-KZO;
- sodium carboxymethyl starch (type A);
- anhydrous colloidal silicon dioxide;
- stearic acid.
The surface of the tablets is covered with a film coating, which is made from the following ingredients:
- glycerol;
- iron oxide yellow dye;
- hypromellose;
- titanium dioxide;
- macrogol;
- magnesium stearate.
Pharmacology:
- promotes the production of norepinephrine and dopamine, thereby stabilizing the psycho-emotional background;
- lifts the mood;
- activates melatonin receptors;
- normalizes body temperature;
- eliminates nightmares, makes sleep sound;
- has an effect on the prefrontal zone of the brain, which consists in stimulating the receptors responsible for the release of dopamine and norepinephrine.
The constituent components are completely absorbed and quickly undergo the metabolic process.
Equilibrium concentration is achieved 1-2 hours after taking the Vildoxan tablet. The active substance is removed from the body with the help of the liver and kidneys.
Pharmacological profile
Valdoxan has the following therapeutic effects on the human body:
- enhances the production of dopamine and norepinephrine, thereby improving mood;
- improves mood and psycho-emotional state;
- stimulates melatonin receptors;
- reduces body temperature;
- normalizes sleep.
It affects the brain, in particular the prefrontal zone, by stimulating certain receptors that enhance the release of norepinephrine and dopamine.
The substances included in the composition are absorbed completely and quickly. Equilibrium concentration is achieved one to two hours after taking the tablets. Metabolism of the active component occurs in the liver.
Protein binding in plasma is greater than 95 percent. The distribution of the substance does not depend on age and the presence of renal dysfunction. In the form of metabolites, it is quickly excreted from the body by the kidneys and during urination.
Price
Valdoxan is dispensed subject to the presence of a prescription sheet.
Recipe in Latin:
Rp: Agomelatini 0.025
DtdN 14 in tab.
- 25 mg 1 time/day in the evening.
You can buy a psychotropic drug in Moscow in a chain of pharmacies or an online pharmacy.
The average price of 28 tablets is 1,600 rubles .
For a package of 14 pills you will have to pay 878 rubles .
"Paroxetine"
The drug "Valdoxan", the instructions for use of which should be carefully studied before taking it, has generics that have an antidepressant effect due to their anti-anxiety effect. Such drugs include Paroxetine.
The drug is indicated for use in the treatment of depression caused by severe stress or chronic anxiety. In this case, the drug has a complex effect: on the one hand, it eliminates the cause of depression, on the other, it eliminates its symptoms and promotes recovery.
Instructions for use
The use of tablets is carried out without reference to food intake.
Take a single dose with 150 ml of water without chewing.
The treatment regimen is developed exclusively by the attending physician, taking into account the etiology of the disease and the physical condition of the patient.
A missed tablet should not be taken as a supplement to the next dose.
Manufacturers made sure that the patient did not miss taking the drug. For this purpose, a calendar is printed on the back of the blister.
Experts recommend taking a psychotropic drug once a day before bed.
A single dose is 25 mg of active substance, which corresponds to one tablet. Sometimes, in the absence of the desired effect, the daily dose is increased to 50 mg (2 pcs.), except for elderly patients. Only a doctor can adjust the dosage, who takes into account the results of tests and liver tests when making a decision.
An antidepressant is prescribed after passing liver tests. When analyzing the result, attention is paid to the level of transaminase. If the indicator exceeds the upper limit of the standard by more than 3 times, then Valdoxan cannot be used in therapy.
The duration of the treatment course for each patient is determined individually. On average, it takes about six months for symptoms of depression to disappear.
After stopping the drug, signs of withdrawal syndrome may appear. To prevent side effects, you need to take a psychotropic drug with a dose reduction towards the end of therapy. After it, your well-being improves significantly, apathy disappears, sleep normalizes, and your mood improves.
special instructions
The experiments conducted indicate a risk of suicidal thoughts, especially in patients under 25 years of age. Therefore, it is important to inform the doctor about previously observed suicide attempts in the patient. In such cases, medical supervision will be necessary.
Since Valdoxan is an antidepressant, it is not allowed to drink alcohol during the course of therapy. Failure to follow this rule may worsen the depressive episode.
In case of liver failure, medical monitoring of the functions of the organ is necessary on the first day of taking the drug, as well as in the third, sixth, twelfth and twenty-fourth weeks. If signs of liver damage occur (darkening of urine, yellow tint of the skin, pain in the right hypochondrium, frequent fatigue), the use of the drug is discontinued.
For kidney disease, a specialist can adjust the dosage of the drug.
Valdoxan interacts with other drugs as follows:
- inhibitors of the CYP1A2 isoenzyme (Ciprofloxacin, Fluvoxamine) - the concentration of agomelatine increases.
- Rifampicin reduces the bioavailability of the active ingredient.
Side effects
During clinical trials, rare cases of adverse events were identified.
Among them, the most common ones are highlighted:
- dizziness;
- nausea;
- headache.
These manifestations do not require discontinuation of the drug; unpleasant symptoms disappear spontaneously during the first 3-5 days.
Key data on the frequency of other signs of antidepressant side effects:
- often – intestinal upset; abdominal pain; increased transaminase levels;
- infrequently – migraine, numbness of certain areas of the skin; itching sensation; hives; increased sweating; noise in ears;
- rarely – a feeling of anxiety that occurs when changing body position, motor movements; change in the amount of enzymes that change the alkaline phosphatase indicator; jaundice; liver failure; erythematous rash; urinary retention.
On the mental side, under the influence of the active substance of the drug, the following manifestations may be observed:
- unreasonable anxiety;
- hallucinations;
- nightmares;
- suicidal behavior.
Additional studies have shown that antidepressants provoke weight gain. In rare cases, you can lose weight on Valdoxan.
"Venlafaxine"
The instructions for use available for Valdoxan, analogues of which we are considering, indicate that the main active ingredient of the medicine is called agomelatine. Venlafaxine also has the same substance as its main component.
The use of Venlafaxine is not recommended in case of heart and vascular diseases, as well as in cases of body weight disorders: severe deficiency or excess. The advantage of the drug is its low cost. Due to the negative effect of the drug on the vascular system, it should not be taken by people suffering from glaucoma or at high risk of developing it, for example, due to a hereditary factor.
Contraindications
In the annotation, the manufacturer indicates some restrictions on the use of psychotropic drugs:
- Allergy to the active substance or other components of the medicine.
- Liver failure or elevated transaminase levels (three times the highest normal level).
- Combination of an antidepressant with inhibitors (CYP1A2 type).
- Age factor (under 18 years of age the drug is not prescribed).
- Hypersensitivity of the body to lactose.
Combination with alcohol
Even with irregular use of alcoholic beverages, the liver and nervous system are primarily affected. The harmful effects of ethanol on the body are as follows:
- after 5 minutes it enters the stomach, in the presence of ulcerative processes and damage to the mucous membrane, it burns through the vulnerable walls of the stomach;
- quickly absorbed into the blood, sharply expanding and narrowing the walls of blood vessels and making them fragile and thin, simultaneously reducing blood pressure;
- concentrated in the brain, irreversibly affects the cells of the cerebral hemispheres, which are responsible for the state of euphoria and for inhibitory reactions, leading to a decrease in brain performance;
- up to 90% of the substance is concentrated in the pancreas and liver, which increases the production of enzymes and enhances the actions of eliminating toxic substances;
- large amounts of urine are excreted through the kidneys and genitourinary system, simultaneously leading to dehydration of internal organs.
Therefore, the compatibility of Valdoxan with ethanol is out of the question, because in this case, irreversible processes occur in the brain and liver, increasing the risk of nervous disorders and new diseases.
Moreover, an important condition here is the body’s predisposition to the development of certain pathologies. This may be a hereditary disease that has not yet manifested itself, but began to develop when drinking alcohol together with an antidepressant. This effect can no longer be reversed, and any illness or weakened immune system will henceforth lead to the appearance of symptoms of this disease.
Precautionary measures
The prescription and further use of a psychotropic drug requires periodic monitoring of test data reflecting liver functionality.
One of the rare side effects is liver damage, which is expressed in a sharp increase in the level of liver enzymes, the development of jaundice, and hepatitis. To prevent such complications, the attending physician refers the patient to laboratory tests to measure transaminase levels.
Minor changes in the liver occur in most patients in the first month of therapy, but then the situation often stabilizes. Upon completion of the course of treatment, all indicators return to normal without additional use of pharmacological agents.
- In clinical trials, less than 300 cases of pregnant women were considered, so it is too early to draw conclusions on the relativity of the effect of the active substance on the body of the expectant mother based on scant information. Animal studies have not shown direct or indirect threats to the female and fetus.
- Also, no negative effects of the antidepressant on the process of delivery or postnatal development were recorded. However, pharmacologists recommend using the drug with caution not only during pregnancy, but also during lactation.
- The ability of the active substance to be absorbed into breast milk is also not known for certain, but data from animal studies confirmed this fact. If a patient who is breastfeeding a child is prescribed the antidepressant Valdoxan, breastfeeding is stopped.
Special attention should be paid to the use of the product elderly people.
The effectiveness of the drug for people over 65 years of age has not been established, but there are instructions from the manufacturer to limit the dosage for this group of patients.
Dosage and regimen of use
Valdoxan is usually prescribed one tablet per day, unless otherwise directed by your doctor. It is recommended to take before going to bed. The tablet must be swallowed completely. It is not advisable to chew or divide the medicine into pieces. The use of the drug does not depend on food intake.
If a therapeutic effect is not observed, the doctor can increase the dosage to 50 milligrams, that is, two tablets per day in the evening.
The duration of use to increase the effectiveness of treatment and prevent relapses of depression is at least six months.
Since the medication does not have a withdrawal effect, there is no need to gradually reduce the dosage before stopping the use of the tablets.
The number of studies conducted regarding the pregnancy period is limited. Therefore, you can take Valdoxan tablets while carrying a child only if a specialist determines that the benefit to the woman will outweigh the risk to the health of the unborn child.
Studies have shown that the active substance passes into breast milk. That is why, when prescribing medication, nursing mothers must stop breastfeeding.
The drug is contraindicated for use by patients under eighteen years of age. Studies have shown that the use of pills in children provokes suicidal behavior, aggressiveness and irritability.
Single cases of overdose have been recorded. In this state, the following reactions occur:
- pain in the epigastric zone;
- worsening anxiety;
- dizziness;
- headache;
- sleep disorders;
- general weakness.
With a slight overdose of Valdoxan, the symptoms go away on their own, and the state of health gradually improves. If disturbances in the functioning of the heart or nervous system are observed, symptomatic therapy is prescribed.
Reviews of people who took the drug
Tatyana, 39 years old:
Valdoxan tablets became a real salvation after my divorce from my husband. She fell into a state of depression imperceptibly: at first there was a desire to isolate herself from the outside world, then the desire to go to work and do ordinary household chores disappeared. My daughter is already an adult, lives separately with her family, and I couldn’t think of anything better than to lie down in a warm bed. A friend literally dragged me to the doctor. Of all the specialist’s recommendations, I only agreed to the antidepressant Valdoxan.
It took at least 2 months before I felt the desire to do something, to create, to create. Six months later, my thoughts were busy with worldly issues, work plans, and most importantly, the desire to live appeared!
Sergey Vladimirovich, 57 years old:
I am a military man, after retirement I slowly lost myself, I did not find a worthy occupation in ordinary life. Unbeknownst to myself, I closed myself off from friends and neighbors and felt worthless. The wife invited an alleged acquaintance to her house, who in fact turned out to be a psychotherapist. The preliminary diagnosis of depression was confirmed after examination at the clinic. The course of treatment was carried out on an outpatient basis. I took Valdoxan for three months.
No side effects were observed throughout the entire therapy. I felt positive dynamics after taking the medicine for a month. A couple of weeks before stopping the drug, the doctor reduced the daily dose to ½ tablet. per day.
PAXIL
Name:
Liliya Kuznetsova
Review:
it helps, but the medicine is painfully expensive
Name:
Andrey Shurupov
Review:
it helps, but the medicine is painfully expensive
Name:
Konstantin Kifaev
Review:
oh well, there’s nothing to save on your health, try luche coke, it helps gee-gee-gee...!!!!!
Name:
Review:
I have been taking Paxil for more than 5 years, 20 mg, 1 tablet a day. Even with gradual withdrawal, heart palpitations, extrasystole and a lump in the throat begin. Mood worsens. The cardiologist advises not to cancel. I want to quit, but I can’t. I come back again and again. Is it possible to endure this condition and finally quit? By following a diet, cholistirin increases to 9. I kindly ask you to answer and advise.
Name:
I)
Review:
I have been taking Paxil for more than 5 years, 20 mg, 1 tablet a day. Even with gradual withdrawal, heart palpitations, extrasystole and a lump in the throat begin. Mood worsens. The cardiologist advises not to cancel. I want to quit, but I can’t. I come back again and again. Is it possible to endure this condition and finally quit? By following a diet, cholistirin increases to 9. I kindly ask you to answer and advise.
Name:
Elena Serkova
Review:
I have been taking Paxil for more than 5 years, 20 mg, 1 tablet a day. Even with gradual withdrawal, heart palpitations, extrasystole and a lump in the throat begin. Mood worsens. The cardiologist advises not to cancel. I want to quit, but I can’t. I come back again and again. Is it possible to endure this condition and finally quit? By following a diet, cholistirin increases to 9. I kindly ask you to answer and advise.
Name:
Alexey DAO
Review:
I took Rexetine for almost a year, almost the same as Paxil. I forgot to take it for a maximum of 1-2 days, then the withdrawal symptoms just hit my head. 2 times unsuccessfully throwing the drug. The 3rd time I pulled myself together and quit. For about a week, powerful pulsation in the temples, especially when bending over. Then less and less often, as a result, the pulsation appeared several times over the course of 2-3 months, apparently it was the body itself playing pranks from memory =) Now I have not taken any pills for about a year and am looking for a good psychiatrist, since the pills were a little better, but not dramatically, after stopping the drug it became even worse...
Name:
krowka_lili booo
Review:
Dear users, I recommend reading this message! I am 24 years old and I first started taking Paxil when I was 19. I was going through a breakup with my first love, and I lay on the bed all day long, I didn’t want anything, there was complete apathy, tears, etc. Paxil helped me a lot the first time, but it turned out to be just an illusion, and unfortunately I realized this only now. When I started taking Paxil, like many others probably, I felt sick, vomited, had terrible cramps in my stomach, after a week all these symptoms went away and complete euphoria set in. Everything that happened to me, it seemed to me that it was not happening to me, but I heard about it somewhere and didn’t take it to heart, my brain worked like in a movie about health care, if anyone watched it. I had crazy energy, I analyzed everything that was happening and didn’t care about it. In a word, I am not a fairy tale. The only thing that bothered me was the dilated pupils. I was prescribed the drug for 3 months, in three months I returned to normal, lost weight, and everything was just wonderful and I easily came off the drug. After some time, I even took it purely to lose weight, to avoid side effects, but I never took it for more than six months. It so happened in my life that in 2008 I received a spinal fracture, naturally it was very difficult emotionally, I started taking the drug again, but also did not take it for too long. After some time, as a result of the injury, I suffered from urinary incontinence. I couldn’t leave the house, as soon as I crossed the threshold of the house I was wet up to my knees. I had to take Paxil again, sometimes I replaced it with Rexitin and plizil, it’s an analogue and differs, in principle, only in price. And the problem with incontinence disappeared, after going to the hospital, the urologist explained to me that I have a neurogenic bladder and incontinence occurs from fear, after an injury, and Paxil helps remove this fear, and advised me to drink it. A year and a half passed, and I realized that these pills are hell!!! All the advantages that I listed are covered by what is happening to me now! This drug is truly a drug. I have been taking it for 1.5 years now, as a result of which I have terrible drowsiness, fatigue, headaches and indifference to everything, plus to everything my pulse is terribly elevated, I can come in the evening to take my pulse and it will be under me 120. Having consulted a doctor, she explained to me that everything that was happening to me was as a result of long-term use of the drug; moreover, I gained a lot of weight, which turned out to be also a result of long-term use! It happened that I could sleep for a day! Firmly deciding to ask to drink this crap, I lowered the dose, and at one point I simply forgot to take the pill and decided not to drink anymore! The next day, my body seemed to be pierced by an electric current, after which I felt dizzy like hell, and started to feel sick, I couldn’t do anything, plus over time, outbursts of emotions, tears, panic, etc. began, I could start crying out of nowhere . It was as if all these 1.5 years the drug was simply blocking all emotions and saving it somewhere. I had to start taking the drug again, but I firmly decided that I would stretch out this pack for two months, gradually reducing the dose, and at the same time I would follow a diet, exercise and go to the solarium to improve my mood!!! Understand that Paxil should NOT be taken for 5 years at a time!!! especially for GIRLS, it completely blocks the emotional background, affects the figure, and most importantly, if a girl becomes pregnant while using the drug, her child may simply be born down ! While taking the drug, you should not drink alcohol or smoke, but we are all not saints, and after 5 years of use, surely someone could afford it. Paxil can be taken for no more than six months in case of really strong changes and disorders in life. You can’t just drink it because it’s hard at work, etc., you’re ruining yourself, your body and psyche. The best medicine will be if you just read more psychological literature and change your consciousness, reprogram your brain, and force yourself to think differently!
Name:
Dmitry Shpak
Review:
Don't trust the instructions. It is very addictive, physical and psychological. If you take it for a long time, the withdrawal symptoms are very strong. By the way, it is similar to cocaine and other central nervous system stimulants.
Name:
Victoria Eliseeva
Review:
Paxil did not help me. I was recommended Bach Rescue Remedy drops, I took them for a month and a half, the result exceeded all expectations. Quickly copes with panic attacks. Now I drink other Bach essences. Natural homeopathic medicine. I highly recommend it. Health to everyone!!!
Name:
Elena Serkova
Review:
What did you replace it with during the year?
Name:
crazy owl
Review:
I was diagnosed with anxiety-phobic disorder. In 2014, I took Paxil from April to August. In June I wanted to quit, but the psychological addiction did not let me go. I changed my lifestyle: more positive moments, walks with friends, thought less about pills, and in August I managed to quit it completely. I just started taking less and less often. A little later I caught myself thinking that I hadn’t taken it for several days. At first I felt some anxiety, but it quickly passed. As for the effect. In the first 10-14 days I experienced a mountain of side effects, it only got worse, but “heroically” I continued taking it and suddenly... I suddenly felt better. Euphoria and a feeling of complete satisfaction with life. It seems that everything will work out. All fears disappeared. After another week, the condition became stable. Positive, but without this wild euphoria. Now I'm having a relapse. I want to go to the psychiatrist again and get a prescription for those drugs. Yes, if you are going somewhere and there are few pills, be sure to take the prescription with you. They don't sell Paxil without it.
Name:
Veshkurov Denis
Review:
sold without a prescription
Name:
Review:
PROMPT FROM REXETINE. PAROXITINE HAS THE SAME SIDES!
Name:
Loo D
Review:
I’ve been taking Paxil for the fourth week, my mood has improved, the headaches have gone away, everything is fine. But I read how to get out of it, I think I can handle it, and then I’m under the supervision of a good psychotherapist.
Name:
Dmitry Mshvenieradze
Review:
I have been taking Paxil for more than 5 years, 20 mg, 1 tablet a day. Even with gradual withdrawal, heart palpitations, extrasystole and a lump in the throat begin. Mood worsens. The cardiologist advises not to cancel. I want to quit, but I can’t. I come back again and again. Is it possible to endure this condition and finally quit? By following a diet, cholistirin increases to 9. I kindly ask you to answer and advise.
Name:
Mikhail Stolbov
Review:
PAXIL is a good drug in terms of clinical effectiveness and tolerability. Refers to antidepressants (3rd generation). The most important side effect of this drug, which causes people to stop taking it, is sexual dysfunction. But it is worth noting that Paxil is the standard in the treatment of OCD and ANXIETY DISORDER!
Name:
Mikhail Stolbov
Review:
I have been taking Paxil for more than 5 years, 20 mg, 1 tablet a day. Even with gradual withdrawal, heart palpitations, extrasystole and a lump in the throat begin. Mood worsens. The cardiologist advises not to cancel. I want to quit, but I can’t. I come back again and again. Is it possible to endure this condition and finally quit? By following a diet, cholistirin increases to 9. I kindly ask you to answer and advise.
Name:
Mikhail Stolbov
Review:
I took rexetine for almost a year, almost the same as Paxil. I forgot to take it for a maximum of 1-2 days, then the withdrawal symptoms just hit my head. 2 times unsuccessfully throwing the drug. The 3rd time I pulled myself together and quit. For about a week, powerful pulsation in the temples, especially when bending over. Then less and less often, as a result, the pulsation appeared several times over the course of 2-3 months, apparently it was the body itself playing pranks from memory =) Now I have not taken any pills for about a year and am looking for a good psychiatrist, since the pills were a little better, but not dramatically, after stopping the drug it became even worse...
Name:
ala lala
Review:
How can you listen to feedback from mentally ill people?
Name:
KOS
Review:
Hello everyone. I decided to write a review about the drug Paxil. So, I started taking Paxil for GAD, OCD, PA. I used to take SSRIs too, but not as strong. I entered the drug gradually, hiding behind trunks. I felt minor side effects for a month. Then my body got used to it and I took it 5 mg per day. Yes, this is a small dose, but it suited me and my condition returned to normal. It got worse as I went up. Everything went away with the drug and I lived and worked peacefully. But you shouldn’t drink it for more than a year. I quit immediately, one day, and regretted it! A week later, CO began. This drug has a strong CO and pronounced. Includes: headaches, vivid restless dreams, anxiety, PA, increased heart rate, strange sensations in the head, and so on. My advice to you is to climb off gradually! And of course pills are not a cure. They will remove all vegetative manifestations so that you can work on yourself and change something in your life. Thank you. Health to everyone!
Name:
Antonina Kalinichenko
Review:
My husband is having a midlife crisis, they prescribed him Paxil, but for me, it only got worse. Now he doesn’t need anything at all, the last potency has disappeared, even smartprost doesn’t help, he’s completely sluggish, lifeless... I expected a completely different effect. And this is how he has it.
Name:
Leonid Formanchuk
Review:
My husband is having a midlife crisis, they prescribed him Paxil, but for me, it only got worse. Now he doesn’t need anything at all, the last potency has disappeared, even smartprost doesn’t help, he’s completely sluggish, lifeless... I expected a completely different effect. And this is how he has it.
Name:
Olga Dmitrieva
Review:
My husband is having a midlife crisis, they prescribed him Paxil, but for me, it only got worse. Now he doesn’t need anything at all, the last potency has disappeared, even smartprost doesn’t help, he’s completely sluggish, lifeless... I expected a completely different effect. And this is how he has it.
Name:
Popov Evgeniy
Review:
I took it for almost 1.5 years. A good drug, but there is a withdrawal syndrome and it would be better to go through it with a doctor. The psychotherapist worked with me for about a year, Paxil was very gradually reduced, we reached 1/4 tablet every other day, but I had to go abroad and then I reduced the dose myself on the doctor’s recommendation, but at one point there was great fear and I, a fool, I increased the dose myself to 1/2 tablet and ruined everything for myself... I pulled myself together 3 months after increasing the dose and got off Paxil myself, it was quite difficult, but I’m sure if I had been under the supervision of a doctor I would have gotten off easily a minimal set of somatic things. And so, the drug helped a lot.
Name:
egik
Review:
Paxil did not help me. I was recommended Bach Rescue Remedy drops, I took them for a month and a half, the result exceeded all expectations. Quickly copes with panic attacks. Now I drink other Bach essences. Natural homeopathic medicine. I highly recommend it. Health to everyone!!!
Reviews from doctors
Tamila Albertovna, neurologist, medical experience 14 years:
From my own experience, I can highlight the effectiveness of the psychotropic drug Valdoxan. But the drug requires a thorough examination of the patient before prescription and dose adjustment throughout therapy. To more accurately determine the treatment regimen, there is a need for the assistance of a psychotherapist.
Olga Vyacheslavovna, medical experience 8 years:
Treatment of depression with Valdoxan tablets is effective in the case of comprehensive diagnosis and individual dosage selection. The first signs of positive dynamics are noticeable after a week of using the medicine. The patient’s mood improves significantly, motivational guidelines and a desire to change their lifestyle appear. Throughout therapy, samples are required to monitor transaminase levels.
VALDOXAN
Name:
Galina Bocharova
Review:
The most stupid and useless thing that could be answered.
Name:
Viziter Viziter
Review:
Read carefully! Galina Bocharova wrote that…. wants !!! woman!!!
Name:
Galina Bocharova
Review:
If everyone is so attentive, then Galina Bocharova wrote: I got sick, recovered, etc.! Idiots, there are no words - well, the person doesn’t have an email address, but he has a desire to share useful information. And instead of reading what they wanted to see (namely, how the drug acts on one individual person (after all, that’s what they came here for!)), they inflated who knows what.
Name:
Tatyana
Review:
After carefully studying the reviews, the depression went away without treatment.
Name:
Galina
Review:
After carefully studying the reviews, the depression went away without treatment.
Name:
Alexa
Review:
If everyone is so attentive, then Galina Bocharova wrote: I got sick, recovered, etc.! Idiots, there are no words - well, the person doesn’t have an email address, but he has a desire to share useful information. And instead of reading what they wanted to see (namely, how the drug acts on one individual person (after all, that’s what they came here for!)), they inflated who knows what.
Name:
Alexa
Review:
After carefully studying the reviews, the depression went away without treatment.
Name:
Alexa
Review:
Prescribed by a neurologist for insomnia. I took one tablet at a time. for the night. 7 days in a row. Even though I haven’t slept, I still can’t sleep. On the 8th day I took 2 tablets, I thought maybe the dosage was too small, but I also couldn’t fall asleep, and I felt disgusting after 2 tablets. In general, there is no result yet, but I decided to finish the pack, maybe the cumulative effect will work..
Name:
Boris Istomin
Review:
I read it and was horrified. There was a word in the hospital. scheme 50-50-100, then 25-25-100, ended with 0-0-50. Now only 25 at night. Sleep was restored and my mood also seemed fine. However, I want to say that the first week was like in a hallucinogenic dream, if I had not been in a hospital under the constant supervision of doctors, I would not have dared to drink it at all, but the drug is good, it begins to act fully only after 14 days!
Name:
Elena Medvedeva
Review:
I took Valdaxan for 3 months, the result was excellent, but after six months everything came back, now I started taking it and will extend it until six months
Name:
Marinchik
Review:
I have been taking it since October 10, 2020 (10 days no effect yet)
Name:
Mlada Lepsi
Review:
I took Valdoxan for a month. The only thing that affected my sleep. 1 tablet at night, I fell asleep like I was falling asleep and for the first 4 hours I slept without dreams, in a dead sleep. Despite the fact that I had problems with sleep. I liked the drug as a strong no more sleeping pills. Switched to stimuloton.
Name:
VB
Review:
Prescribed by a neurologist for insomnia. I took one tablet at a time. for the night. 7 days in a row. Even though I haven’t slept, I still can’t sleep. On the 8th day I took 2 tablets, I thought maybe the dosage was too small, but I also couldn’t fall asleep, and I felt disgusting after 2 tablets. In general, there is no result yet, but I decided to finish the pack, maybe the cumulative effect will work..
Name:
Anastasia
Review:
The effect is no earlier than a month later. Sleep only normalizes at first. I have been taking the drug for 1.5 months, my mood has improved, my sleep has returned to normal, my anxiety and constant depressing thoughts have gone away. I can’t say that it’s normal, but it’s gotten better. Among the side effects, fatigue and a little impact on vision.
Name:
Alexey Kolesov
Review:
Guys, this is tough. I read the instructions and realized that it was just a drug and it scared me even more. I won't drink it. And the doctor needs to be given the brains to attribute such things
Name:
Professor
Review:
the mildest of all antidepressants and without major side effects, most importantly, it does not kill libido and is not addictive
Name:
Artem Teply
Review:
Accepted since October 10, 2020 (10 days no effect yet)
Name:
Azat Petrovich
Review:
Excellent drug, no lethargy or drowsiness, I took it for 3 months, no side effects, vitality appears and my mood is good.
Name:
Alexandr
Review:
For the authors: In the description, in the “Pharmacological action” section, the drug may still enhance the release of dopamine, and not some “dopamine”.
Name:
ffff hhh
Review:
Excellent device, no side effects. I drank for 5 months, abruptly quit, depression went away, panic went away. Valdoxan is generally a harmless drug, the effect is after 2 weeks of use.
Analogs
Pharmacological companies also produce substitutes for Valdoxan, but for the treatment of depression only the attending physician is responsible for selecting medications.
Among the popular analogues:
- Azafen (RUR 224);
- Venlafaxine (RUR 348);
- Neuroplant (RUR 210);
- Deprim (RUR 237);
- Zoloft (457 RUR), etc.
A structural analogue is the drug Agomelatine ; other drugs are included in the same pharmacological group.
Independent choice of an analogue can lead to a deterioration in health and the development of complications of the disease. Many active substances, instead of getting rid of alarming symptoms, become real poison. Therefore, the course of therapy should be carried out under the supervision of a specialist .
Why are antidepressants needed?
Depression can be reactive and endogenous. In the first case, we are talking about a reaction to severe stress, any external stimulus. The human psyche is sometimes capable of overcoming this illness on its own or with the help of psychotherapist sessions. Endogenous depression has internal causes, namely an imbalance of biogenic amines: serotonin, norepinephrine, melatonin, or dopamine. When any of these neurotransmitters are insufficient, depression gradually begins to develop. And it is possible to cope with it by medicinally eliminating the deficiency of the missing amine.
Thus, all antidepressants are divided into groups, each of which serves as a means to restore a specific neurotransmitter. The drug itself and Valdoxan analogues belong to the group of serotonin antidepressants, that is, the active component of these drugs promotes the accumulation of this substance in the brain and prevents its breakdown by inhibition and reuptake.
"Sertraline"
"Sertraline" is an antidepressant, the indications for use of which are: depression, panic disorder, consequences of severe stress. The drug has a high level of effectiveness. But, at the same time, it also has a wide list of side effects from various body systems: cardiovascular, immune, digestive, nervous, respiratory and genitourinary.
If the drug is well tolerated by the patient, it produces an excellent therapeutic effect. If a person has a recurrent course of depression, the drug can be used as a prophylaxis in small doses.
"Agomelatine"
The instructions for use describing the drug "Valdoxan" allow you to find analogues by active substance. The composition, and therefore the effect, is similar to Valdoxan, the drug Agomelatine. For depression of moderate severity, a visible improvement occurs after two weeks of taking the drug.
During special studies, it was revealed that the effectiveness of Agomelatine is approximately the same as that of other antidepressants with a similar composition and effect. However, it is much better tolerated. The patients participating in the study experienced virtually no dizziness, nausea, or sexual dysfunction associated with antidepressants.
