Mydocalm in injections: what the drug helps with, instructions for use, indications, contraindications, side effects

Mydocalm injections are, like the tableted drug, a centrally acting muscle relaxant of the aminoketone group. According to the instructions for use, Mydocalm injection solution has an antispastic effect, is able to relieve pain, hypertonicity of muscles affected by neurological symptoms, dystonia, without affecting the entire central nervous system.

Since Mydocalm injection is intended for intramuscular or intravenous action, it does not irritate the mucous membrane of the stomach and intestines, while acting almost immediately after parenteral administration. The main properties of the drug are membrane stabilizing and local anesthetic. In addition, the ability of the drug to control the conduction of nerve impulses along the brain stem, enhance peripheral blood circulation, and exhibit a slight antispasmodic effect has been noted.

Composition of the drug and forms of production

Hungarian offers the drug Mydocalm in two forms of release - tablets for oral use and glass ampoules for intravenous or intramuscular infusions. The active ingredient in the medication is tolperisone hydrochloride. A standard tablet contains 50 or 150 mg, while ampoules contain 100 mg of the active ingredient.

One dark glass ampoule contains 1 ml of solution and includes 2.5 mg of lidocaine hydrochloride. The composition of Mydocalm is supplemented by secondary ingredients: methylparaben, water for injection and diethylene glycol monoethyl ether. A standard cardboard pack contains 5 ampoules.

Is Mydocalm an antibiotic or not?

Mydocalm does not belong to antibiotics, being a representative of the category of centrally acting muscle relaxants. Accordingly, when treating infectious diseases, the drug does not exhibit antimicrobial or antiviral activity, which requires the addition of a full-fledged antibiotic to therapy.

What to choose: Mydocalm tablets or ampoules?

Mydocalm tablets have the same effectiveness, but act more slowly due to a longer period of absorption into the blood from the gastrointestinal tract. Thus, the use of Mydocalm-Richter injections intramuscularly in adult patients is indicated if it is necessary to quickly stop a convulsive syndrome or muscle spasm.

In addition, a dosage of 100 mg of tolperisone is intermediate between the dosages of tablets of 50 mg and 150 mg, thereby filling a vacant niche.

Drug interactions

The active ingredient of the drug has the ability to increase the concentration of the active components of such drugs:

• "Perphenazine";
• "Metoprolol";
• "Desipramine";
• Thioridazon, etc.

Mydocalm has a slight sedative effect, so the dosage should be reduced when using other muscle relaxants. The drug enhances the effect of non-steroidal anti-inflammatory drugs.

Pharmacokinetics

After the solution enters muscle cells or a vessel, tolperisone quickly interacts with albumin in the blood plasma, reaching its highest concentration in 2-3 minutes, but the process of its metabolites is still unknown. When giving an intravenous injection, T ½ is approximately 90 minutes.

As for lidocaine, with maximum absorption and a Cmax time of half an hour, it quickly spreads throughout all systems and tissues of the body. It is important to note that lidocaine can cross the placental threshold and be extracted into breast milk, so Mydocalm should not be used during pregnancy. Tolperisone is excreted through the liver and kidneys, while lidocaine is mainly extracted through the gallbladder.

Pharmacological properties

pharmacodynamics. Centrally acting muscle relaxant. The exact mechanism of action is unknown. As a result of membrane-stabilizing and local anesthetic effects, it prevents the conduction of excitation in primary afferent fibers, blocking mono- and polysynaptic reflexes of the spinal cord. The secondary mechanism of action is to block transmitter release by blocking the entry of calcium ions into synapses. Reduces reflex readiness in the reticulospinal tracts of the brain stem. Reduces increased muscle tone and rigidity caused by decerebration of animals during the experiment. Strengthens peripheral blood circulation. This effect is not related to the effect of the drug on the central nervous system. It may be due to the weak antispasmodic and antiadrenergic effects of tolperisone. Pharmacokinetics. Subject to intense metabolism in the liver and kidneys. It is excreted by the kidneys, 99% in the form of metabolites. The pharmacological activity of the metabolites is unknown. With intravenous administration, T½ is about 1.5 hours.

Indications for use

According to the instructions for use of Mydocalm injections, the following painful conditions, syndromes and pathologies are included in the indications for use of the solution:

• spasms or excessive skeletal muscle tone resulting from central nervous system pathologies, including stroke, myelopathy, encephalic myelitis;
• spasms and excessive tone of muscle contractures, characteristic of diseases of the musculoskeletal system, including arthrosis, spondylosis, osteochondrosis, arthrosis of the joints;
• rehabilitation therapy after surgery;
• advanced treatment of CVS pathologies;
• muscular dystonia;
• encephalopathy of various origins.

Additionally, Mydocalm injections help with spasms of smooth muscles in internal organs, so it is often used for various types of colic and inflammation, including acute prostatitis.

Tolperisone: instructions for use, cost, reviews, analogues

Tolperisone is a medicine intended for the treatment of increased skeletal muscle tone. The drug belongs to the group of centrally acting muscle relaxants.

Under the influence of the drug, muscle tone is restored to a physiologically normal state, motor activity is normalized and pain is eliminated.

Contents of the article: Release form and properties Indications for use Method of use of the drug Analogs and price of the drug Tolperisone Reviews from patients

Release form, composition

Tolperisone is available in the form of tablets for oral administration of 50 and 150 mg. The active substance is tolperisone hydrochloride.

pharmachologic effect

The drug is a centrally acting muscle relaxant. The pharmacological effectiveness of the drug Tolperisone is aimed at relaxing skeletal muscles. The exact mechanism of action of this drug has not been fully studied to date.

The use of the drug Tolperisone contributes to the following effects on the central nervous system:

• blocking spinal reflexes;
• helps reduce the toxicity of the alkaloid stryquinine, which causes increased reflex excitability.

In addition, a moderate antispasmodic, membrane-stabilizing and vasodilating effect is observed. The use of Tolperisone can reduce the pain sensitivity of peripheral nerve endings, reduce pain, and also facilitate voluntary motor activity.

The use of the drug does not contribute to the effect on the peripheral nervous system.

Tolperisone is absorbed in the gastrointestinal tract and excreted by the kidneys.

Indications

Tolperisone is used in complex treatment regimens:

• Spinal and central paralysis, which are accompanied by hypertonicity, muscle spasms, spinal automatism, contracture of the limbs.
• Diseases that manifest themselves in the form of dystonia, rigidity, muscle spasms.
• Obliterating diseases of the arteries in the form of atherosclerosis of the vessels of the extremities, Raynaud's syndrome, diabetic angiopathy, Buerger's disease.
• Post-thrombotic disorders, which are accompanied by disturbances in the microcirculation of blood and lymph. With the development of ulcerative lesions in the lower leg area.
• Epilepsy and cephalopathy of vascular origin.
• Hypertonicity, which is combined with disorders of muscle tone of another type.
• Infantile spastic paralysis (Litt's disease).
• Extrapyramidal disorders (postencephalitic and atherosclerotic parkinsonism).

Tolperisone can be used in the complex treatment of spondyloarthrosis and arthrosis of large joints.

Mode of application

Treatment begins with the minimum effective dose, which is selected by the doctor individually. Gradually the dosage can be increased.

Tolperisone tablets are used after the main meal, washed down with a sufficient amount of plain water. The drug should not be sucked or chewed.

In case of overdose, the likelihood of developing unwanted side reactions increases. In this case, you must immediately stop taking the drug, rinse your stomach and seek medical help.

The duration of treatment is also determined by the attending physician. The drug is not intended for self-medication.

Adverse reactions

The use of the drug Tolperisone can provoke the development of:

• headache;
• myasthenia gravis;
• lowering blood pressure;
• vomiting and nausea;
• gastralgia;
• allergic manifestations in the form of anaphylactic shock, urticaria, bronchospasms, skin itching, rashes.

If the described or any other side effects develop, it is recommended to consult a doctor. In the future, it may be necessary to adjust the dosage or replace the drug with another one.

Contraindications

The use of Tolperisone is contraindicated in case of myasthenia gravis and intolerance to the active or auxiliary substances.

Pregnant and lactating women, as well as patients who have not reached the age of 1 year, will have to avoid using the drug.

Interaction with other drugs

The effectiveness of the drug Tolperisone may increase if used simultaneously:

• with agents that contribute to the provision of a general anesthetic effect;
• with medications from the group of peripheral muscle relaxants;
• with drugs that promote psychoactive effects;
• with clonidine-based drugs that have hypotensive and sedative effects.

Tolperisone can be used in complex treatment regimens together with other drugs prescribed by the doctor. The doctor should be informed what medications the patient is currently taking or has recently used.

Analogues, cost

The cost of Tolperizon for the period March 2020 is formed as follows:

• Tablets 150 mg, 30 pcs. – 190-240 rub.
• Tablets 50 mg, 30 pcs. – 200-206 rub.

An analogue of Tolperisone is the drug Mydocalm. If you need to select a replacement, you should first consult with your doctor and agree on the dosage of the medicine.

Additional recommendations

During treatment with Tolperisone, patients should be extremely careful when driving vehicles and performing work that requires increased attention.

The medicine should be stored in accordance with the manufacturer's recommendations: in a dry place, protected from children and direct sunlight. The optimal storage temperature is no more than 25 degrees.

The drug is a prescription drug.

Reviews

“I purchased Tolperisone as a budget replacement for Mydocalm; these drugs are similar in their action and active substance. The doctor recommended taking the drug as needed, in courses for the treatment of lumbar osteochondrosis. From time to time, severe pain arose in the lower leg and thigh area, and it was impossible to do without the drug.

The next exacerbation of the disease occurred several years later, this time I was bothered by severe pain in the neck. I tried using warming patches and ointments - the effect was short-lived and the pain returned again.

There was no way to see a neurologist, and then I remembered that I had previously taken Tolperisone for a similar problem. I bought this drug again and took it according to the instructions. Then she nevertheless turned to the doctor, osteochondrosis of the cervical spine was detected and the treatment was supplemented with B vitamins, Diclofenac in injections and a vitamin complex with folic acid.

After the course of treatment I notice noticeable improvements. During complex treatment, taking Tolperisone helped to cope with the symptoms of stiffness of movement and pain, so I can recommend this remedy to people who are faced with the problem of osteochondrosis.”

Natalia

“I have been bothered by lower back pain for a long time; the symptom occurs periodically and always goes away on its own after rest. I recently moved and by evening my back hurt so badly that neither Ibuprom painkillers nor rubbing with Fastum gel helped.

I went to the doctor, who advised me to take a course of the muscle relaxant Tolperisone. After rereading the instructions and familiarizing myself with the contraindications and side effects, at first I didn’t want to take the pills, but the MRI results revealed a herniated disc and treatment had to be started as soon as possible.

First, it was necessary to take [information about the dose of the drug was deleted] of the drug, in addition to this, Milgamma injections were prescribed. After completing the course of vitamin therapy, the doctor advised taking Tolperisone for another week. During treatment, no side effects occurred and the drug was well tolerated. As a result: severe back pain went away, the drug helped me quickly return to my normal lifestyle.

To be on the safe side, the doctor said that you can take the painkiller Arcoxia if the effect of Tolperisone is not enough. If possible, it is best to complement drug treatment with physical therapy.

Of course, such medications are not intended for self-medication and are best used only after consultation with a doctor, who will select the exact dosage and tell you which regimen is best for taking the tablets and which medications they can be combined with. Overall, it’s a decent muscle relaxant drug.”

Victor

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Directions for use and dosage

The annotation for the drug states that it is enough to inject one ampoule twice a day into the buttock area. It is possible to administer 1 ml intravenously once a day, but Mydocalm must first be diluted in 10 ml of saline solution.

The effect of the injection appears within 20-30 minutes, while the general course of treatment is determined by the actual condition of the patient and the current need to suppress spasms. Most patients receive injections for 3-7 days in a row. The duration of therapy can be either increased or decreased, depending on the indications.

Mydocalm instructions for use injections

When using injections, the drug must be administered intramuscularly and is 200 mg per day, divided into two mandatory applications. It can also be administered intravenously, but this is done slowly and only 100 mg once a day. The instructions do not contain other information that could place restrictions on the use of the drug, even simultaneously with sedatives or hypnotics. MIDOKALM RICHTER is popular , the instructions for which are strictly individual and require compliance with basic standards.

Analogues of the drug Mydocalm and prices

In the group of centrally acting muscle relaxants, there is a whole range of n-anticholinergics, which may well act as substitutes for Mydocalm, since they are produced in the same form and have similar pharmacodynamics.

Like Mydocalm, you can buy them at the pharmacy only with a prescription:

• Nothrixum;
• Ridelat-S;
• Tracrium;
• Mivacron;
• Aperomide;
• Pipecuronium bromide;
• Croiron;
• Esmeron;
• Ditylin;
• Listenone;
• Tolisor;
• Tolperisone hydrochloride;
• Tubocurarine;
• Nimbex.

The cost of the most effective and common drugs, both Russian and foreign, is presented in the table:

Analogs

• Sirdalud, tablets. Composition: 2 mg tizanidine. Price: 215 rub. for 30 pieces.
• Sirdalud MR, modified release capsules. Composition: 6 mg tizanidine. Price: 530 rub. for 30 pieces.
• Baklosan, tablets. Ingredients: 10 mg baclofen. Price: 260 rub. for 50 tablets.
• Tizanil, tablets. Composition: 2.288 mg tizanidine hydrochloride. Price: 160 rub. for 30 pieces.
• Lioresal Intrathecal, solution for intrathecal administration. Composition: 0.05 mg baclofen per ampoule. Price: 2000 rub. per ampoule.

Known contraindications

There is a list of restrictions that should be considered contraindications to the use of Mydocalm:

• hypersensitivity to the components of the solution;
• myasthenia gravis;
• patients under 18 years of age;
• pregnancy;
• lactation period.

Mydocalm cannot be prescribed during breastfeeding and pregnancy for two reasons: the penetration of lidocaine into milk and placenta, as well as the lack of clinical data on testing the drug on these categories of patients (as well as on persons under 18 years of age).

Contraindications, side effects and overdose

The list of contraindications is small. People prone to allergies, as well as those patients who have been found to be hypersensitive to the components of the drug, should not use the medicine. Mydocalm tablets are not prescribed to newborn babies who are not yet 1 year old. Myasthenia gravis is also a contraindication to therapy with the drug under discussion.

The likelihood of adverse reactions due to the use of the drug is low, but it does exist.

Most often, patients encounter the following unpleasant symptoms:

• headache;
• changes in blood pressure;
• vomiting and nausea;
• skin rashes;
• increased heart rate;
• swelling, localized mainly on the face and hands;
• noise in ears;
• decreased performance, etc.

As a rule, these effects disappear after discontinuation of the drug. In rare cases, after taking the pills, patients experience insomnia, nosebleeds, anemia, angina pectoris, bradycardia, etc. Anaphylactic shock is also possible.

There is no reliable information about cases of overdose. Studies have been conducted using animals.

In experimental animals, due to the use of the drug at a dose higher than the recommended one, the following disorders were observed:

• tonic-clinical convulsions;
• ataxia;
• paralysis of the respiratory center.

If the patient accidentally or intentionally took a high dose, you should do a gastric lavage, drink a drug with an absorbent effect (activated carbon, “White sorbent”, etc.) and, if necessary, contact a medical facility or call an ambulance.

There is no specific antidote for muscle relaxant. Symptomatic therapy is carried out aimed at stabilizing the patient's condition.

Reviews from doctors

Sergey Borisovich M, general practitioner.

Mydocalm is an effective measure for suppressing muscle spasms, which is especially noticeable in the treatment of post-operative or post-traumatic conditions. The drug is considered modern and relatively affordable.

Oleg Semenovich G, rheumatologist.

With all the advantages of Mydocalm, I try to recommend domestic drugs to my patients, since they are always cheaper. Otherwise, the medicine successfully performs its tasks without causing harm to the body.

Effect on the body and properties of Mydocalm

The drug Mydocalm was developed to quickly eliminate painful muscle spasms and relieve muscle hypertonicity. An effective muscle relaxant relieves symptoms of many ailments of the musculoskeletal system and the consequences of stroke. The drug stabilizes the functions of the central nervous system. The medication also relieves inflammation in the muscles. It is used not only for muscle spasms, but also in the treatment of arthrosis of large joints, as well as for rehabilitation after surgery. Prescribed by a doctor.

The drug acts on peripheral nerves. Medicine:

• inhibits the conduction of impulses in neurons and nerve fibers;
• blocks spinal and other reflexes;
• inhibits high reflex excitability of the spinal cord.

Tolperisone is an N-anticholinergic that slows down the process of excitation in the human body. The medication also has a moderate anesthetic effect, so it is used after surgery for injury. The drug does not have a negative effect on the kidneys and liver, is low-toxic and safe for adults. However, it should be taken with caution in cases of severe renal and liver failure.

Mydocalm does not have a direct effect on the cerebral cortex. Maintains the required speed of reactions when a person is awake. Has a moderate adrenergic blocking effect.

Absorption, distribution and excretion from the body

After entering the body, the drug is absorbed in the intestines. The bioavailability of medicinal substances increases the intake of fatty foods. The maximum concentration of tolperisone is observed 1 hour after administration of the drug into the body.

Tolperisone is quickly distributed throughout organic tissues. Metabolism of active compounds occurs in the kidneys and liver. Almost completely the medicine is excreted in the urine.

Patient reviews

Gennady, 35 years old.

I took Mydocalm for about two weeks for severe cramps in my legs caused by a car accident. I can say that in comparison with other drugs in my treatment, this medicine did not cause me any problems or discomfort.

Leonid, 52 years old.

My mother suffered from frequent cramps, spasms, and pain due to arthrosis of her knees, so when I chose her medication, it was important that it did not cause more suffering. Contrary to fears, Mydocalm injections turned out to be completely painless thanks to lidocaine, so we resolved this issue successfully.

special instructions

the drug contains lidocaine, therefore, in case of known hypersensitivity to lidocaine and other amide local anesthetics, Midostad Combi solution for injection should not be used due to the ability to develop allergic reactions. Use during pregnancy and breastfeeding. According to animal studies, tolperisone does not have a teratogenic effect. The use of the medicine in the first trimester of pregnancy is contraindicated. Due to the lack of significant clinical data, the use of the drug in the second and third trimester of pregnancy is likely when, in the opinion of the doctor, the expected benefit significantly outweighs the potential risk to the fetus/child. Since it is unknown whether tolperisone passes into breast milk, the use of the medication during breastfeeding is contraindicated. Children. Midostad Combi injection solution should not be used in children. The ability to influence the reaction speed when driving vehicles or working with other mechanisms. Midostad Combi does not affect the ability to drive vehicles or operate other machinery. If a patient experiences dizziness or muscle weakness while taking the medicine, he should refrain from driving vehicles or operating other machinery.

Mydocalm price

The price of Mydocalm tablets ranges from 294 to 499 rubles for 30 pieces. and depends on the amount of active ingredient in 1 pill . The table shows the prices of tablets in pharmacies:

Video

How to take Mydocalm

A regimen for taking a muscle relaxant based on tolperisone is prescribed by a doctor based on the indications for its use. The instructions for the drug Mydocalm tablets contain general recommendations for using the drug. The medicine should be taken after meals to increase the bioavailability of tolperisone. The tablet must be swallowed whole with water.

Recommended initial doses of Mydocalm depend on the age of the patient. For children aged 3 to 7 years, the drug is prescribed at the rate of 5 mg per 1 kg of child weight three times a day . Children over 7 years old take 3-5 mg of tolperisone per 1 kg of body weight three times a day. Adult patients over 14 years of age take 100-150 mg per day (divided into 3 doses). During the course of treatment, the dosage is gradually increased to 450 mg per day.