The compatibility of Trittico and alcohol can cause dangerous mental disorders, drowsiness, a sharp decrease in blood pressure, and bradycardia. Despite the fact that the drug effectively fights alcoholism, regular mixing of ethyl alcohol with the drug will neutralize the therapeutic effect, and in severe cases will lead to coma or death.
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Indications for starting the drug
You should start taking Trittico for the following diseases:
- Presence of impotence.
- Apathy of hypogenic form.
- Development of involutional depressions.
- Cerebral atherosclerosis.
- Apathy during prolonged pain syndrome.
- Dementia due to old age.
- Alcohol disease.
- Certain phobias in the human body.
- Libido disturbance.
- For active prevention of migraine.
- Bulimia.
- A certain amount of anxiety in the body.
- Apathy due to developing Alzheimer's disease.
- Development of blues at the psychogenic level.
- Presence of anxiety syndromes.
- Patient's benzodiazepine addiction.
Special contraindications to the use of the medicine:
- The presence of hypersensitivity to any component in the drug.
- Development of tachycardia.
- Development of arterial hypertension.
- Pregnancy or breastfeeding.
- The child's age is up to six years.
- Liver or kidney failure.
- History of priapism.
- Development of symptoms of gastric extrasystole.
- The initial stage of recovery after a heart attack.
- Arterial type hypertension.
Indications and contraindications
The drug Trittico is indicated for use in the following cases:
- Benzodiazepine addiction.
- Depressive conditions that are accompanied by increased anxiety due to Alzheimer's disease, dementia or cerebral atherosclerosis.
- Violation of the normal emotional state due to prolonged pain.
- Alcoholism (acute alcohol syndrome) and psychogenic depression.
- Disorders of libido and potency that could be provoked by depressive disorders.
- Increased fatigue and slow thinking.
- Bulimia, phobias.
- Constant acute migraine attacks.
- Suicidal attempts.
Contraindications include:
- Pregnancy and lactation period.
- Hypersensitivity or complete intolerance to the components of the product.
- Arrhythmia and tachycardia.
Trittico tablets should be taken with particular caution in case of the following diseases:
- Kidney and liver failure.
- Arterial hypertension.
- Atrioventricular block.
- History of priapism.
- Myocardial infarction.
You should be careful when taking these tablets after a recent heart attack, as they may adversely affect the functioning of the heart.
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Pregnancy and lactation
Clinical studies have not shown any undesirable effects on pregnancy or the condition of the fetus. Data from animal studies have not shown the detrimental effect of Trittiko on the development of the embryo, fetus, pregnancy and childbirth.
It is recommended to exercise caution and monitor the baby's condition after birth to ensure timely detection of possible withdrawal syndrome. Limited data indicate that trazodone passes into breast milk, therefore breastfeeding should be discontinued during treatment.
Interaction with other tools
The active substance Trittico reacts with other medications. To avoid negative consequences, before starting treatment you need to inform the doctor about all the medications the patient is taking.
The simultaneous use of tradozone and substances that depress the central nervous system increases the effect of the drugs. The drug Trittico increases the sedative and anticholinergic effect:
- Haloperidol;
- Pimosidan;
- Loxapina;
- Thioxanthene;
- tricyclic antidepressants.
MAO inhibitors and CYP3A4 blockers in combination with trazodone provoke the development of side effects.
Rules for drinking with alcohol
Alcohol and trittico are completely incompatible. These substances cannot only be taken simultaneously, but also sequentially. A certain time period must pass between treatment with this drug and drinking alcohol.
It is necessary to take into account the half-life of the drug from the body, as well as the time of exposure to alcohol in the body. It is recommended not to drink alcohol earlier than two days after the last dose of Trittico. The drug should be resumed two days after the last drink.
Narcologist : “Trittiko is an antidepressant that can be used in combination with other medications to treat alcohol addiction. It helps combat depression while treating withdrawal symptoms. However, the simultaneous use of trittiko and alcohol is strictly prohibited. Patients who ignore this rule often end up in the intensive care unit.”
Interaction between trittico and alcohol
Trittico, like the breakdown products of ethyl alcohol, simultaneously affects two organs - the brain and liver. A sharp deterioration in the general condition of a practically healthy person with this combination is associated with damage to these organs.
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The main target of both substances is the central nervous system. Alcohol initially causes euphoria, increased mood, and decreased anxiety. Then, as the dose increases, drowsiness, lethargy, and decreased response to external stimuli occur. Trittico acts in the opposite way - first it causes drowsiness and lethargy, and then an improvement in mood.
The points of application of the two substances are almost the same. Trittico affects serotonin metabolism, thereby helping to fight depression. Ethyl alcohol affects all monoamines - mediators responsible for the emotional-volitional sphere. In this case, a sharp rise in the concentration of serotonin, dopamine and norepinephrine may occur, and then a rapid decrease in their quantity.
Consequences of co-administration
Clinically, simultaneous use of trittico with alcohol can manifest itself as mental disorders: hallucinations, delusions, manic state. In addition, pathological drowsiness and impaired consciousness may occur, leading to coma. There is also a high probability of developing dysfunction of the autonomic nervous system, which manifests itself in a decrease in blood pressure, a decrease in heart rate, and depression of the respiratory center. In severe cases, death is possible.
In order for trittico and alcohol breakdown products to be eliminated from the body, they must first be metabolized in the liver. In this organ they bind to the same structures, thus preventing each other from being eliminated. Thus, both the medication and the alcohol will circulate in the blood unchanged for a long time, causing a toxic effect on the liver.
Possible consequences of incorrect alignment
You cannot combine Trittico and alcohol.
This can lead to the development of the following symptoms:
- anemia;
- agranulocytosis;
- allergy;
- disruption of vasopressin production;
- decreased appetite;
- suicidal tendencies;
- hallucinations;
- nightmares;
- aggressiveness;
- convulsions;
- memory impairment;
- increased feeling of anxiety;
- arrhythmia;
- bradycardia;
- disturbance of the ECG pattern;
- dyspnea;
- changes in blood pressure;
- liver dysfunction;
- myalgia;
- urinary disturbance.
Trittico should not be taken after alcohol under any circumstances. This causes severe negative symptoms and exacerbation of the existing disease.
Composition and effect of the medicine
Trittiko tablets do not have an anticholinergic effect.
This means that it can be taken even by older people. The drug does not adversely affect the body in cases of prostatic hypertrophy and closed-angle glaucoma. But still the medicine has its side effects:
- Increased fatigue and excessive sleepiness.
- Feeling of bitterness in the mouth.
- Hypotension and the manifestation of skin allergic reactions.
- Paresthesia, severe headaches.
- Arrhythmia and dizziness.
- Feeling of constant dry mouth.
- Increased arousal state.
- Anorexia.
- Severe pain and disorientation.
- Neutropenia.
- Myalgia.
- Nausea and diarrhea.
- Eye irritation.
- Tremor.
- Leukopenia and bradycardia.
- Low blood pressure and impaired coordination of movements.
- Vomiting reflex.
- Epileptic seizures and respiratory arrest.
Most of the above side effects occur due to excessive use of Trittico, that is, an overdose.
Many patients are interested in whether it is possible to combine taking Trittico tablets with alcoholic beverages. No, this is strictly prohibited. Alcohol increases blood pressure, and medication can dramatically lower it. As a result, all this can lead to the development of hypoxia, that is, a lack of oxygen levels in the body. The patient will immediately feel very bad - he will experience severe dizziness. The person may even faint.
When taking alcoholic beverages and the specified medication at the same time, slow oxidation of alcohol will occur in the body, which can lead to serious poisoning. Sometimes problems arise with the central nervous system. The patient becomes lethargic and lifeless. If you do not stop drinking alcohol, the situation may worsen. Breathing disorders and coma are possible.
The danger of simultaneous use of alcohol and Trittico tablets lies in the destructive effect that occurs on the patient’s liver. The drug is eliminated from the body through this internal organ.
Drinking alcohol can lead to a sharp deterioration in liver function and its complete intoxication. More severe consequences are also possible - the patient may develop toxic hepatitis in a complex form.
Doctors definitely say that simultaneous consumption of Trittico and alcoholic beverages cannot lead to the patient’s recovery. All therapeutic treatment will not bring any positive results. The effect of the tablets will be stopped by alcohol.
If the side effects of the drug are serious, it is recommended to contact a medical specialist who can adjust the therapeutic treatment and prescribe a different dose of Trittico tablets.
Trittico, instructions for which are included in the package, is produced in the form of tablets that are white in color. The main component of the drug is trazodone hydrochloride. The medicine is also developed on the basis of magnesium stearate, carnauba wax, polyvinylpyrrolidone and sucrose.
The active ingredient of the drug is trazodone hydrochloride. Its concentration in one tablet corresponds to the dosage of the medication indicated on the package. Excipients are sucrose, wax, magnesium stearate and povidone. The low concentration of excipients in each tablet does not allow them to have any effect on the body.
For children
Children under 6 years of age should not use Trittico tablets. After this age, treatment is permitted for medical reasons. The daily amount of the drug ranges from 1.5 to 3 mg/kg. The dosage is divided into 2-3 doses. If necessary, it is gradually increased to 6 mg/kg per day.
In pediatrics, antidepressants from the triazolopyridine group are used in extreme cases. During therapy, careful monitoring of the child's condition is necessary. The active substance can increase suicidal tendencies and provoke aggressive behavior in minor patients.
Instructions for use
To avoid side effects of Trittico tablets, the correct dosage must be observed. Usually it is prescribed by a doctor individually, depending on what disease needs to be cured. The attending physician must first conduct a thorough examination of the patient.
Much depends on blood tests. If a person has a deficiency of white blood cells, a large dosage can only worsen his health, since the drug will further reduce the number of white blood cells.
Under no circumstances should you take Trittico on your own. Everything is strictly individual. At the beginning of using this drug, the dosage is usually increased and then reduced. Thus, it is possible to avoid many side effects of taking the medicine.
Features of taking the drug:
- The initial dose for adult patients should not exceed 150 mg per day, twice daily.
- It is advisable to use the tablets before bed, as they may cause severe dizziness.
- If necessary, the doctor will recommend increasing the daily dose by another 50 mg. The maximum daily dose for outpatients should not be more than 450 mg, and for inpatients – 600 mg.
- Elderly people and immunocompromised patients should not take more than 75 mg of the drug per day.
- For mild forms of depression, you can take a prophylactic drug of no more than 150 mg per three days with two-day breaks.
For alcohol dependence, it is recommended to take the drug half an hour before meals or a couple of hours after meals. The minimum dosage is 100 mg once a day. Gradually, the doctor may increase the amount of the drug. The tablet should be consumed whole, without chewing and with plenty of water.
Efficacy of the drug
The antidepressant is characterized by the absence of anticholinergic action. That is why its use is allowed for elderly patients. The drug is characterized by the absence of negative effects on the body if the patient has angle-closure glaucoma or pancreatic hypertrophy. Despite this, the medication is characterized by the presence of certain undesirable effects:
- Taking the medicine incorrectly can lead to increased agitation.
- Some patients complain of bitterness in the mouth.
- Undesirable effects may include excessive drowsiness and fatigue.
- If the medication is taken incorrectly, hypotension can be diagnosed, as well as allergies, which have a variety of clinical manifestations on the skin.
- Taking the medication may be accompanied by arrhythmia and dizziness.
- Sometimes patients experience severe weight loss, even to the point of anorexia.
- Undesirable effects may include disorientation or severe pain.
- After taking the medication, patients may be diagnosed with neuropenia or sialgia.
- Patients often complain of nausea and vomiting after taking the medication.
- Some of the patients are diagnosed with leukopenia or bradycardia.
- Side effects in some cases include tremors of the limbs or irritation of the eyes.
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Most side effects in patients are observed when taking the medication in excessively large quantities. To avoid unwanted effects, you should consult your doctor before taking the medicine. If the patient experiences adverse reactions, the medication must be discontinued.
The main feature of Trittico tablets is that the effect is achieved very quickly - for most people. Fear, irritability, insomnia, and chronic headaches cease to bother the patient. The time spent awake is significantly reduced, and the quality of sleep actually improves.
An excellent effect also manifests itself, if necessary, in stabilizing the patient’s emotional state and improving his mood. The drug is highly effective in treating withdrawal symptoms in people dependent on benzodiazepines. The medicine helps restore male strength.
In 50% of patients, the positive effects of Trittico tablets appear within 2-3 days after regular use of the drug. But 25% see the effect of using the drug only after two weeks.
When using Trittico, adverse reactions from the brain, heart, hematopoietic organs, digestive system and genitals are possible.
Tremor is a common side effect, and many patients also develop fatigue and drowsiness, and may have a headache. Less often, on the contrary, unmotivated excitement occurs. Very rare side effects from the central nervous system include incoordination of movements and disorientation in space.
Trittico often causes a decrease in blood pressure and persistent hypotension, especially in people prone to fluctuations in blood pressure. In addition, the occurrence or worsening of supraventricular or ventricular blockades and other forms of brady- and tachyarrhythmias may occur. On the part of the hematopoietic system, there is often a decrease in hemoglobin, red blood cells and leukocytes to the lower limit of normal or a mild degree of anemia and leukopenia.
A rather rare side effect, compared to other antidepressants, is a decrease in appetite. Even less common are dyspeptic disorders or transient bitterness in the mouth. Allergic reactions to the drug are also rare.
One of the most adverse side effects of Trittico is priapism. Priapism is an erection not associated with sexual arousal that causes pain and requires immediate treatment. This side effect is also rare.
Precautionary measures
During therapy using Trittico, it is important to adhere to some rules:
- Conduct blood tests periodically. Under the influence of the drug, changes in the indicators of leukocytes or neutrophils are possible.
- Male patients with prolonged and inadequate erections should consult a doctor to adjust the treatment regimen.
- If surgery is planned while taking the pills, the antidepressant should be discontinued in advance.
- One of the side effects is dry mouth, which can provoke the development of dental diseases. To prevent unpleasant consequences, it is recommended to use sugar-free candies or chewing gum during the course of therapy.
- Antidepressants reduce concentration, so during treatment it is worth eliminating any risks.
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Overdose
Use of the drug in doses exceeding therapeutic doses increases the risk of developing undesirable effects. The most common symptoms of Trittico overdose are nausea, headache and drowsiness. Less commonly, hypotension, decreased heart rate, or ventricular tachyarrhythmias occur. In severe cases, overdose is accompanied by impaired consciousness up to coma, convulsions and respiratory failure of central origin.
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There is no specific antidote for trittico. In case of overdose, it is recommended to follow the same procedures as for any other poisoning. You should immediately call an ambulance station. Then - induce a gag reflex in the patient, give an enema or give a laxative. If possible, it is necessary to rinse the stomach. In severe cases, hospitalization in the intensive care unit is required.
Indications for use
The properties described in the instructions for the drug Trittico determine its use in various forms of depressive conditions, in the complex treatment of alcoholism, and in the treatment of nervous system disorders. Indications for the use of an antidepressant are:
- somatogenic, psychotic, neurotic or endogenous depression;
- decreased libido and sexual activity;
- insomnia and other sleep disorders;
- appetite and eating disorders (bulimia, anorexia);
- increased fatigue, chronic fatigue syndrome;
- various phobias, obsessive states;
- dependence on benzodiazepine drugs.
Pharmacodynamics and pharmacokinetics
The high rate of absorption of the drug means it enters the circulatory system through the intestines.
Interaction with plasma proteins - 90-95%. It is excreted from the body through the kidneys and bile.
Trazodone, being a triazolopyridine derivative, has a predominantly antidepressant effect, with some sedative and anxiolytic effects. Trazodone has no effect on MAO, which distinguishes it from MAO inhibitors and tricyclic antidepressants.
Quickly affects mental (affective tension, irritability, fear, insomnia) and somatic symptoms of anxiety (palpitations, headache, muscle pain, frequent urination, sweating, hyperventilation).
Trazodone is effective for sleep disorders in patients with depression, increases the depth and duration of sleep, and restores its physiological structure and quality.
Trazodone stabilizes the emotional state, improves mood, reduces pathological craving for alcohol in patients suffering from chronic alcoholism during the period of alcohol withdrawal syndrome, also in remission. For withdrawal symptoms in patients suffering from dependence on benzodiazepine derivatives, trazodone is effective in the treatment of anxiety, depression and sleep disorders. During remission, benzodiazepines can be completely replaced by trazodone.
The drug is not addictive.
Helps restore libido and potency, both in patients with depression and in people who do not suffer from depression.
The mechanism of action of trazodone is associated with the high affinity of the drug for certain subtypes of serotonin receptors, with which trazodone enters into an antagonistic or agonistic interaction depending on the subtype, as well as with the specific ability to cause inhibition of serotonin reuptake.
The neutral uptake of norepinephrine and dopamine has little effect.
The drug does not affect body weight.
Absorption of the drug from the gastrointestinal tract after oral administration is high. Taking trazodone during or immediately after a meal slows the rate of absorption, reduces Cmax of the drug in blood plasma and increases Tmax. Tmax of the drug is achieved 1/2–2 hours after oral administration.
The drug penetrates histohematic barriers, as well as into tissues and fluids (bile, saliva, breast milk).
Plasma protein binding is 89–95%.
Trazodone is metabolized in the liver, the active metabolite is 1-m-chlorophenylpiperazine. T1/2 in the first phase is 3-6 hours, in the second phase - 5-9 hours. The majority of the metabolized drug is excreted through the kidneys, in the urine (about 75%) and is completely completed 98 hours after taking the drug, excreted in the bile about 20%.
In vitro studies on human microsomes have shown that trazodone is primarily metabolized by cytochrome P450 CYP3A4.
Use in childhood
The use of Trittico is contraindicated for the treatment of children under 6 years of age.
Particular caution should be exercised when prescribing Trittico to patients under the age of 18 years.
At the age of 6 to 18 years, the dose is prescribed, taking into account the patient’s weight, at the rate of 1.5–2 mg per 1 kg of body weight per day and divided into several doses. If necessary, the initial dose can be gradually increased, maintaining an interval of 3 –4 days. The maximum daily dose should not exceed 6 mg per 1 kg of body weight.
special instructions
Instructions for use Trittico recommends taking the drug with caution in case of interruptions in blood pressure (arterial hypertension or hypotension). Due to the adrenolytic activity of trazodone, bradycardia may occur; therefore, if the patient has a history of myocardial infarction, it is necessary to carefully monitor pressure changes during therapy.
According to the observations of doctors, the sedative effect caused by taking Trittico can impair the speed of psychomotor reactions and reduce attention. During the treatment period, it is recommended to avoid activities that require high precision. For children and adolescents from 6 to 18 years old, persons with impaired liver and kidney function, the drug can be prescribed for acute conditions.
Serotonin syndrome, agranulocytosis
Serotonin syndrome or neuroleptic malignant syndrome may develop during simultaneous therapy with Trittico with the following groups of drugs:
- tricyclic antidepressants;
- SSRIs;
- MAO inhibitors;
- norepinephrine and serotonin reuptake inhibitors;
- neuroleptics.
Neuroleptic malignant syndrome is a dangerous condition that threatens the patient’s life, therefore the simultaneous use of drugs from these groups with Trittico is strictly contraindicated.
Agranulocytosis is manifested by a symptomatic complex characteristic of influenza: sore throat, fever, chills, weakness. In this case, blood laboratory values should be checked.
